Trends of Metformin Use in Patients with Hidradenitis Suppurativa, 2016-2021

Introduction: Hidradenitis Suppurativa (HS) is a dermatologic condition that is comorbid with diabetes mellitus (DM) and polycystic ovarian syndrome (PCOS). Metformin has been used as a therapy in DM and PCOS, but little research has been done to see if it is being used in patients with HS. Methods: Using MarketScan, information on HS, DM, and PCOS diagnoses were collected from January 1, 2016 through December 31, 2021. Metformin prescription information was also collected on these patients. Results: During the study, the percentage of HS patients with a metformin prescription increased (Z =-9.6, p<0.001). Metformin prescriptions in patients with HS but without DM or PCOS diagnoses also increased (Z=-13.1, p<0.001). Discussion: Metformin offers promising therapeutic options for the treatment of patients with HS, even if they do not have comorbid conditions.