TRPC channels in smooth muscle cells

Jose C. Gonzalez-Cobos, Mohamed Trebak

Research output: Contribution to journalReview articlepeer-review

75 Scopus citations


Transient receptor potential canonical (TRPC) proteins constitute a family of seven (TRPC1-7) nonselective cation channels within the wider TRP superfamily. TRPC1, TRPC3, TRPC4, TRPC5 and TRPC6 channels are expressed in vascular smooth muscle cells from human vessels of all calibers and in smooth muscle from organs such as the uterus and the gastrointestinal tract. TRPC channels have recently emerged as important players in the control of smooth muscle function. This review will focus on the retrospective analysis of studies proposing contributions of TRPC channels to native calcium entry pathways in smooth muscle and to physiological and pathophysiological responses with emphasis on the vascular system.

Original languageEnglish (US)
Pages (from-to)1023-1039
Number of pages17
JournalFrontiers in Bioscience
Issue number3
StatePublished - Jun 1 2010

All Science Journal Classification (ASJC) codes

  • General Biochemistry, Genetics and Molecular Biology
  • General Immunology and Microbiology


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