TY - JOUR
T1 - Tryptophan catabolism generates autoimmune-preventive regulatory T cells
AU - Fallarino, Francesca
AU - Grohmann, Ursula
AU - You, Sylvaine
AU - McGrath, Barbara Claire
AU - Cavener, Douglas R.
AU - Vacca, Carmine
AU - Orabona, Ciriana
AU - Bianchi, Roberta
AU - Belladonna, Maria L.
AU - Volpi, Claudia
AU - Fioretti, Maria C.
AU - Puccetti, Paolo
PY - 2006/12
Y1 - 2006/12
N2 - Tryptophan catabolism is a tolerogenic effector system in regulatory T cell function, yet the general mechanisms whereby tryptophan catabolism affects T cell responses remain unclear. We provide evidence that its effects include the emergence of a regulatory phenotype in naive CD4+CD25- cells via the general control non-depressing 2 (GCN2) protein kinase mediated induction of the forkhead transcription factor Foxp3. These cells are capable of effective control of diabetogenic T cells in vivo.
AB - Tryptophan catabolism is a tolerogenic effector system in regulatory T cell function, yet the general mechanisms whereby tryptophan catabolism affects T cell responses remain unclear. We provide evidence that its effects include the emergence of a regulatory phenotype in naive CD4+CD25- cells via the general control non-depressing 2 (GCN2) protein kinase mediated induction of the forkhead transcription factor Foxp3. These cells are capable of effective control of diabetogenic T cells in vivo.
UR - http://www.scopus.com/inward/record.url?scp=36248996016&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=36248996016&partnerID=8YFLogxK
U2 - 10.1016/j.trim.2006.09.017
DO - 10.1016/j.trim.2006.09.017
M3 - Article
C2 - 17157218
AN - SCOPUS:36248996016
SN - 0966-3274
VL - 17
SP - 58
EP - 60
JO - Transplant Immunology
JF - Transplant Immunology
IS - 1
ER -
