Tryptophan catabolism generates autoimmune-preventive regulatory T cells

Francesca Fallarino, Ursula Grohmann, Sylvaine You, Barbara Claire McGrath, Douglas R. Cavener, Carmine Vacca, Ciriana Orabona, Roberta Bianchi, Maria L. Belladonna, Claudia Volpi, Maria C. Fioretti, Paolo Puccetti

Research output: Contribution to journalArticlepeer-review

97 Scopus citations


Tryptophan catabolism is a tolerogenic effector system in regulatory T cell function, yet the general mechanisms whereby tryptophan catabolism affects T cell responses remain unclear. We provide evidence that its effects include the emergence of a regulatory phenotype in naive CD4+CD25- cells via the general control non-depressing 2 (GCN2) protein kinase mediated induction of the forkhead transcription factor Foxp3. These cells are capable of effective control of diabetogenic T cells in vivo.

Original languageEnglish (US)
Pages (from-to)58-60
Number of pages3
JournalTransplant Immunology
Issue number1
StatePublished - Dec 2006

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology
  • Transplantation


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