Tryptophan catabolism generates autoimmune-preventive regulatory T cells

Francesca Fallarino; Ursula Grohmann; Sylvaine You; Barbara Claire McGrath; Douglas R. Cavener; Carmine Vacca; Ciriana Orabona; Roberta Bianchi; Maria L. Belladonna; Claudia Volpi; Maria C. Fioretti; Paolo Puccetti

doi:10.1016/j.trim.2006.09.017

Tryptophan catabolism generates autoimmune-preventive regulatory T cells

Francesca Fallarino
, Ursula Grohmann
, Sylvaine You
, Barbara Claire McGrath
, Douglas R. Cavener
, Carmine Vacca
, Ciriana Orabona
, Roberta Bianchi
, Maria L. Belladonna
, Claudia Volpi
, Maria C. Fioretti
, Paolo Puccetti

Research output: Contribution to journal › Article › peer-review

103 Scopus citations

Abstract

Tryptophan catabolism is a tolerogenic effector system in regulatory T cell function, yet the general mechanisms whereby tryptophan catabolism affects T cell responses remain unclear. We provide evidence that its effects include the emergence of a regulatory phenotype in naive CD4⁺CD25^- cells via the general control non-depressing 2 (GCN2) protein kinase mediated induction of the forkhead transcription factor Foxp3. These cells are capable of effective control of diabetogenic T cells in vivo.

Original language	English (US)
Pages (from-to)	58-60
Number of pages	3
Journal	Transplant Immunology
Volume	17
Issue number	1
DOIs	https://doi.org/10.1016/j.trim.2006.09.017
State	Published - Dec 2006

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

All Science Journal Classification (ASJC) codes

Immunology and Allergy
Immunology
Transplantation

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10.1016/j.trim.2006.09.017

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title = "Tryptophan catabolism generates autoimmune-preventive regulatory T cells",

abstract = "Tryptophan catabolism is a tolerogenic effector system in regulatory T cell function, yet the general mechanisms whereby tryptophan catabolism affects T cell responses remain unclear. We provide evidence that its effects include the emergence of a regulatory phenotype in naive CD4+CD25- cells via the general control non-depressing 2 (GCN2) protein kinase mediated induction of the forkhead transcription factor Foxp3. These cells are capable of effective control of diabetogenic T cells in vivo.",

author = "Francesca Fallarino and Ursula Grohmann and Sylvaine You and McGrath, \{Barbara Claire\} and Cavener, \{Douglas R.\} and Carmine Vacca and Ciriana Orabona and Roberta Bianchi and Belladonna, \{Maria L.\} and Claudia Volpi and Fioretti, \{Maria C.\} and Paolo Puccetti",

year = "2006",

month = dec,

doi = "10.1016/j.trim.2006.09.017",

language = "English (US)",

volume = "17",

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journal = "Transplant Immunology",

issn = "0966-3274",

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TY - JOUR

T1 - Tryptophan catabolism generates autoimmune-preventive regulatory T cells

AU - Fallarino, Francesca

AU - Grohmann, Ursula

AU - You, Sylvaine

AU - McGrath, Barbara Claire

AU - Cavener, Douglas R.

AU - Vacca, Carmine

AU - Orabona, Ciriana

AU - Bianchi, Roberta

AU - Belladonna, Maria L.

AU - Volpi, Claudia

AU - Fioretti, Maria C.

AU - Puccetti, Paolo

PY - 2006/12

Y1 - 2006/12

N2 - Tryptophan catabolism is a tolerogenic effector system in regulatory T cell function, yet the general mechanisms whereby tryptophan catabolism affects T cell responses remain unclear. We provide evidence that its effects include the emergence of a regulatory phenotype in naive CD4+CD25- cells via the general control non-depressing 2 (GCN2) protein kinase mediated induction of the forkhead transcription factor Foxp3. These cells are capable of effective control of diabetogenic T cells in vivo.

AB - Tryptophan catabolism is a tolerogenic effector system in regulatory T cell function, yet the general mechanisms whereby tryptophan catabolism affects T cell responses remain unclear. We provide evidence that its effects include the emergence of a regulatory phenotype in naive CD4+CD25- cells via the general control non-depressing 2 (GCN2) protein kinase mediated induction of the forkhead transcription factor Foxp3. These cells are capable of effective control of diabetogenic T cells in vivo.

UR - https://www.scopus.com/pages/publications/36248996016

UR - https://www.scopus.com/pages/publications/36248996016#tab=citedBy

U2 - 10.1016/j.trim.2006.09.017

DO - 10.1016/j.trim.2006.09.017

M3 - Article

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AN - SCOPUS:36248996016

SN - 0966-3274

VL - 17

SP - 58

EP - 60

JO - Transplant Immunology

JF - Transplant Immunology

IS - 1

ER -

Tryptophan catabolism generates autoimmune-preventive regulatory T cells

Abstract

UN SDGs

All Science Journal Classification (ASJC) codes

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