TY - JOUR
T1 - Tumor carbohydrate antigens and strategies to develop cancer vaccines and drugs
AU - Liu, Min
AU - Pan, Qin
AU - Luo, Fengling
AU - Meyers, Craig
AU - Zhang, Xiao Lian
N1 - Funding Information:
Received date: 2012-09-12 Foundation item: Supported by the National Outstanding Youth Foundation of China (81025008), the National Natural Science Foundation of China (30921001, 30800038, 31270176 and 81000714), the National Grand Program on Important Infectious Disease (2012ZX10003002-015), the National Basic Research Program of China (973 Program, 2009CB522507 and 2012CB720604). Biography: LIU Min, female, Lecturer, Ph.D., research direction: glycobiol-ogy and immunology. E-mail: [email protected]. LIU Min, PAN Qin, and LUO Fengling contributed equally to this work. † To whom correspondence should be addressed. E-mail: zhangxiaolian@whu. edu.cn.
PY - 2013/2
Y1 - 2013/2
N2 - Certain carbohydrate antigens of malignantly transformed cells have been identified as markers for the onset of cancer and have become targets for the development of anticancer vaccine therapies. For tumor antigens, many carbohydrate antigens belong to T-independent (TI) antigens. Carbohydrate conjugated to protein carriers can switch TI antigen to a T-dependent (TD) antigen. Attempts to add an innate immune response element (such as Toll-like receptor ligand) to carbohydrate TI-antigens have also been studied. Glycosylation inhibitors or small interfering RNA have also been used for antitumor and/or antiviral agents. This review aims at describing the vast spectrum of tumor carbohydrate antigens and strategies to develop cancer vaccines and drugs.
AB - Certain carbohydrate antigens of malignantly transformed cells have been identified as markers for the onset of cancer and have become targets for the development of anticancer vaccine therapies. For tumor antigens, many carbohydrate antigens belong to T-independent (TI) antigens. Carbohydrate conjugated to protein carriers can switch TI antigen to a T-dependent (TD) antigen. Attempts to add an innate immune response element (such as Toll-like receptor ligand) to carbohydrate TI-antigens have also been studied. Glycosylation inhibitors or small interfering RNA have also been used for antitumor and/or antiviral agents. This review aims at describing the vast spectrum of tumor carbohydrate antigens and strategies to develop cancer vaccines and drugs.
UR - http://www.scopus.com/inward/record.url?scp=84873345705&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84873345705&partnerID=8YFLogxK
U2 - 10.1007/s11859-013-0885-0
DO - 10.1007/s11859-013-0885-0
M3 - Article
AN - SCOPUS:84873345705
SN - 1007-1202
VL - 18
SP - 1
EP - 8
JO - Wuhan University Journal of Natural Sciences
JF - Wuhan University Journal of Natural Sciences
IS - 1
ER -
