Tumor Cell Biodiversity Drives Microenvironmental Reprogramming in Liver Cancer

Lichun Ma; Maria O. Hernandez; Yongmei Zhao; Monika Mehta; Bao Tran; Michael Kelly; Zachary Rae; Jonathan M. Hernandez; Jeremy L. Davis; Sean P. Martin; David E. Kleiner; Stephen M. Hewitt; Kris Ylaya; Bradford J. Wood; Tim F. Greten; Xin Wei Wang

doi:10.1016/j.ccell.2019.08.007

Tumor Cell Biodiversity Drives Microenvironmental Reprogramming in Liver Cancer

Lichun Ma
, Maria O. Hernandez
, Yongmei Zhao
, Monika Mehta
, Bao Tran
, Michael Kelly
, Zachary Rae
, Jonathan M. Hernandez
, Jeremy L. Davis
, Sean P. Martin
, David E. Kleiner
, Stephen M. Hewitt
, Kris Ylaya
, Bradford J. Wood
, Tim F. Greten
, Xin Wei Wang

Department of Surgery

Research output: Contribution to journal › Article › peer-review

670 Scopus citations

Abstract

Ma et al. perform single-cell RNA sequencing of primary liver cancers and find heterogeneity in malignant cells and in the tumor microenvironment, the degree of which negatively associates with patient prognosis. They demonstrate that VEGF expression is linked to tumor diversity and T cell dysfunction.

Original language	English (US)
Pages (from-to)	418-430.e6
Journal	Cancer Cell
Volume	36
Issue number	4
DOIs	https://doi.org/10.1016/j.ccell.2019.08.007
State	Published - Oct 14 2019

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

All Science Journal Classification (ASJC) codes

Oncology
Cancer Research

Access to Document

10.1016/j.ccell.2019.08.007

Cite this

Ma, L., Hernandez, M. O., Zhao, Y., Mehta, M., Tran, B., Kelly, M., Rae, Z., Hernandez, J. M., Davis, J. L., Martin, S. P., Kleiner, D. E., Hewitt, S. M., Ylaya, K., Wood, B. J., Greten, T. F., & Wang, X. W. (2019). Tumor Cell Biodiversity Drives Microenvironmental Reprogramming in Liver Cancer. Cancer Cell, 36(4), 418-430.e6. https://doi.org/10.1016/j.ccell.2019.08.007

@article{2820ac0993b348c397563ae027a9b95e,

title = "Tumor Cell Biodiversity Drives Microenvironmental Reprogramming in Liver Cancer",

abstract = "Ma et al. perform single-cell RNA sequencing of primary liver cancers and find heterogeneity in malignant cells and in the tumor microenvironment, the degree of which negatively associates with patient prognosis. They demonstrate that VEGF expression is linked to tumor diversity and T cell dysfunction.",

author = "Lichun Ma and Hernandez, \{Maria O.\} and Yongmei Zhao and Monika Mehta and Bao Tran and Michael Kelly and Zachary Rae and Hernandez, \{Jonathan M.\} and Davis, \{Jeremy L.\} and Martin, \{Sean P.\} and Kleiner, \{David E.\} and Hewitt, \{Stephen M.\} and Kris Ylaya and Wood, \{Bradford J.\} and Greten, \{Tim F.\} and Wang, \{Xin Wei\}",

note = "Publisher Copyright: {\textcopyright} 2019",

year = "2019",

month = oct,

day = "14",

doi = "10.1016/j.ccell.2019.08.007",

language = "English (US)",

volume = "36",

pages = "418--430.e6",

journal = "Cancer Cell",

issn = "1535-6108",

publisher = "Cell Press",

number = "4",

}

TY - JOUR

T1 - Tumor Cell Biodiversity Drives Microenvironmental Reprogramming in Liver Cancer

AU - Ma, Lichun

AU - Hernandez, Maria O.

AU - Zhao, Yongmei

AU - Mehta, Monika

AU - Tran, Bao

AU - Kelly, Michael

AU - Rae, Zachary

AU - Hernandez, Jonathan M.

AU - Davis, Jeremy L.

AU - Martin, Sean P.

AU - Kleiner, David E.

AU - Hewitt, Stephen M.

AU - Ylaya, Kris

AU - Wood, Bradford J.

AU - Greten, Tim F.

AU - Wang, Xin Wei

PY - 2019/10/14

Y1 - 2019/10/14

N2 - Ma et al. perform single-cell RNA sequencing of primary liver cancers and find heterogeneity in malignant cells and in the tumor microenvironment, the degree of which negatively associates with patient prognosis. They demonstrate that VEGF expression is linked to tumor diversity and T cell dysfunction.

AB - Ma et al. perform single-cell RNA sequencing of primary liver cancers and find heterogeneity in malignant cells and in the tumor microenvironment, the degree of which negatively associates with patient prognosis. They demonstrate that VEGF expression is linked to tumor diversity and T cell dysfunction.

UR - https://www.scopus.com/pages/publications/85072931594

UR - https://www.scopus.com/pages/publications/85072931594#tab=citedBy

U2 - 10.1016/j.ccell.2019.08.007

DO - 10.1016/j.ccell.2019.08.007

M3 - Article

C2 - 31588021

AN - SCOPUS:85072931594

SN - 1535-6108

VL - 36

SP - 418-430.e6

JO - Cancer Cell

JF - Cancer Cell

IS - 4

ER -

Tumor Cell Biodiversity Drives Microenvironmental Reprogramming in Liver Cancer

Abstract

UN SDGs

All Science Journal Classification (ASJC) codes

Access to Document

Other files and links

Fingerprint

Cite this