Turning induced by unilateral injection of antimicrotubular agents into the substantia nigra

Mark R. Brann; Molly Finnerty; John Ellis; Robert H. Lenox; Yigal H. Ehrlich

doi:10.1016/S0278-5846(82)80104-8

Turning induced by unilateral injection of antimicrotubular agents into the substantia nigra

Mark R. Brann, Molly Finnerty, John Ellis, Robert H. Lenox, Yigal H. Ehrlich

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Abstract1.Male Sprague-Dawley rats were given unilateral injections of colchicine, vinblastine, or saline into the substantia nigra pars compacta.2.The injection of vinblastine or colchicine produced a motor imbalance which was manifested as a turning away (contralateral rotation) from the injected side. This effect decreased over a period of days.3.These data suggest that disruption of microtubule-dependent systems within the nigra may result in a functional stimulation of the nigrostriatal pathway.

Original language	English (US)
Pages (from-to)	347-350
Number of pages	4
Journal	Progress in Neuropsychopharmacology and Biological Psychiatry
Volume	6
Issue number	4-6
DOIs	https://doi.org/10.1016/S0278-5846(82)80104-8
State	Published - 1982

All Science Journal Classification (ASJC) codes

Pharmacology
Biological Psychiatry

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10.1016/S0278-5846(82)80104-8

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@article{2bbf6c1b81dc4bc8a40e15d2bcaf9174,

title = "Turning induced by unilateral injection of antimicrotubular agents into the substantia nigra",

abstract = "Abstract1.Male Sprague-Dawley rats were given unilateral injections of colchicine, vinblastine, or saline into the substantia nigra pars compacta.2.The injection of vinblastine or colchicine produced a motor imbalance which was manifested as a turning away (contralateral rotation) from the injected side. This effect decreased over a period of days.3.These data suggest that disruption of microtubule-dependent systems within the nigra may result in a functional stimulation of the nigrostriatal pathway.",

author = "Brann, {Mark R.} and Molly Finnerty and John Ellis and Lenox, {Robert H.} and Ehrlich, {Yigal H.}",

note = "Funding Information: The authors gratefully acknowledge the expert secretarial assistance of Ginger McDowell, and the thoughtful advice and support of Dr. Miles Hacker. This research was supported in part by grant 02747 from NIDA to Dr. Ehrlich and by grant POl CA24543 from NCI to the Vermont Regional Cancer Center.",

year = "1982",

doi = "10.1016/S0278-5846(82)80104-8",

language = "English (US)",

volume = "6",

pages = "347--350",

journal = "Progress in Neuropsychopharmacology and Biological Psychiatry",

issn = "0278-5846",

publisher = "Elsevier Inc.",

number = "4-6",

}

TY - JOUR

T1 - Turning induced by unilateral injection of antimicrotubular agents into the substantia nigra

AU - Brann, Mark R.

AU - Finnerty, Molly

AU - Ellis, John

AU - Lenox, Robert H.

AU - Ehrlich, Yigal H.

N1 - Funding Information: The authors gratefully acknowledge the expert secretarial assistance of Ginger McDowell, and the thoughtful advice and support of Dr. Miles Hacker. This research was supported in part by grant 02747 from NIDA to Dr. Ehrlich and by grant POl CA24543 from NCI to the Vermont Regional Cancer Center.

PY - 1982

Y1 - 1982

N2 - Abstract1.Male Sprague-Dawley rats were given unilateral injections of colchicine, vinblastine, or saline into the substantia nigra pars compacta.2.The injection of vinblastine or colchicine produced a motor imbalance which was manifested as a turning away (contralateral rotation) from the injected side. This effect decreased over a period of days.3.These data suggest that disruption of microtubule-dependent systems within the nigra may result in a functional stimulation of the nigrostriatal pathway.

AB - Abstract1.Male Sprague-Dawley rats were given unilateral injections of colchicine, vinblastine, or saline into the substantia nigra pars compacta.2.The injection of vinblastine or colchicine produced a motor imbalance which was manifested as a turning away (contralateral rotation) from the injected side. This effect decreased over a period of days.3.These data suggest that disruption of microtubule-dependent systems within the nigra may result in a functional stimulation of the nigrostriatal pathway.

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U2 - 10.1016/S0278-5846(82)80104-8

DO - 10.1016/S0278-5846(82)80104-8

M3 - Article

C2 - 6187044

AN - SCOPUS:0020465784

SN - 0278-5846

VL - 6

SP - 347

EP - 350

JO - Progress in Neuropsychopharmacology and Biological Psychiatry

JF - Progress in Neuropsychopharmacology and Biological Psychiatry

IS - 4-6

ER -

Turning induced by unilateral injection of antimicrotubular agents into the substantia nigra

Abstract

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