Abstract1.Male Sprague-Dawley rats were given unilateral injections of colchicine, vinblastine, or saline into the substantia nigra pars compacta.2.The injection of vinblastine or colchicine produced a motor imbalance which was manifested as a turning away (contralateral rotation) from the injected side. This effect decreased over a period of days.3.These data suggest that disruption of microtubule-dependent systems within the nigra may result in a functional stimulation of the nigrostriatal pathway.
|Number of pages
|Progress in Neuropsychopharmacology and Biological Psychiatry
|Published - 1982
All Science Journal Classification (ASJC) codes
- Biological Psychiatry