Two weeks of interval training enhances fat oxidation during exercise in obese adults with prediabetes

Julian M. Gaitán, Natalie Z.M. Eichner, Nicole M. Gilbertson, Emily M. Heiston, Arthur Weltman, Steven K. Malin

Research output: Contribution to journalArticlepeer-review

14 Scopus citations


Prediabetes is associated with impaired oxidative capacity and altered substrate utilization during exercise. The effects of continuous (CONT) versus interval (INT) exercise training on fat oxidation during an acute exercise bout at the same absolute and relative intensities are unknown in this population. Obese fe-males/males (n = 17, n = 5) with prediabetes (BMI 32.2 ± 1.2 kg.m-2; age 62.8 ± 1.6 y; fasting glucose 103.4 ± 1.6 mg.dL-1; 2-hour glucose 153.7 ± 7.1 mg.dL-1; VO2peak 19.9 ± 1.0 were screened with a 75g OGTT. Subjects completed a peak oxygen consumption test and a submaximal exercise substrate utilization test consisting of 5min stages at absolute (30W) and relative (70%HRpeak) intensities before and after randomiza-tion to 12 sessions (60min each) of CONT (70% HRpeak) or INT (alternating 3min 90% HRpeak, 3min 50% HRpeak) over a two-week period. Body mass decreased and VO2peak increased more after INT than CONT (INT:-0.6 ± 0.2 kg, CONT:-0.1 ± 0.2 kg; p = 0.04; INT: 1.9 ± 0.6 mL/kg/min, CONT: 0.1 ± 0.6; p = 0.04). Training increased fat oxidation by 0.7 ± 0.2 during the absolute intensity test (p < 0.001), independent of intensity. During the relative intensity test, fat oxidation increased more after INT than CONT (INT: 1.3 ± 0.4, CONT: 0.3 ± 0.3; p = 0.03), with no difference in exercise energy expenditure between groups. Enhanced fat oxidation during the relative test was correlated with increased VO2peak (r = 0.53 p = 0.01). High intensity INT training enhances fat oxidation during the same relative intensity exercise in people with prediabetes.

Original languageEnglish (US)
Pages (from-to)636-644
Number of pages9
JournalJournal of Sports Science and Medicine
Issue number4
StatePublished - Dec 2019

All Science Journal Classification (ASJC) codes

  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation


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