TY - JOUR
T1 - Two weeks of interval training enhances fat oxidation during exercise in obese adults with prediabetes
AU - Gaitán, Julian M.
AU - Eichner, Natalie Z.M.
AU - Gilbertson, Nicole M.
AU - Heiston, Emily M.
AU - Weltman, Arthur
AU - Malin, Steven K.
N1 - Funding Information:
Authors contributed to either conceptualization, implementation of experiments, data collection, and/or analysis and interpretation. All authors contributed to writing/editing of the manuscript. We thank Dr. Eugene J. Barrett for providing medical oversight. We also thank the members of the Applied Metabolism & Physiology lab for helpful discussion on the manuscript and assistance conducting the study. We thank the Clinical Research Unit nursing staff, the Exercise Physiology Core Lab staff, and the participants for their dedication to the study. This work was supported by the University of Virginia Curry School of Education and Launchpad Award to S.K.M. This study complied with the laws of the country of the authors’ affiliation. The authors have no conflicts of interests to declare.
Funding Information:
Authors contributed to either conceptualization, implementation of experiments, data collection, and/or analysis and interpretation. All authors contributed to writing/editing of the manuscript. We thank Dr. Eugene J. Barrett for providing medical oversight. We also thank the members of the Applied Metabolism & Physiology lab for helpful discussion on the manuscript and assistance conducting the study. We thank the Clinical Research Unit nursing staff, the Exercise Physiology Core Lab staff, and the participants for their dedication to the study. This work was supported by the University of Virginia Curry School of Education and Launchpad Award to S.K.M. This study complied with the laws of the country of the authors? affiliation. The authors have no conflicts of interests to declare.
Publisher Copyright:
© Journal of Sports Science and Medicine.
PY - 2019/12
Y1 - 2019/12
N2 - Prediabetes is associated with impaired oxidative capacity and altered substrate utilization during exercise. The effects of continuous (CONT) versus interval (INT) exercise training on fat oxidation during an acute exercise bout at the same absolute and relative intensities are unknown in this population. Obese fe-males/males (n = 17, n = 5) with prediabetes (BMI 32.2 ± 1.2 kg.m-2; age 62.8 ± 1.6 y; fasting glucose 103.4 ± 1.6 mg.dL-1; 2-hour glucose 153.7 ± 7.1 mg.dL-1; VO2peak 19.9 ± 1.0 mL.kg-1.min-1) were screened with a 75g OGTT. Subjects completed a peak oxygen consumption test and a submaximal exercise substrate utilization test consisting of 5min stages at absolute (30W) and relative (70%HRpeak) intensities before and after randomiza-tion to 12 sessions (60min each) of CONT (70% HRpeak) or INT (alternating 3min 90% HRpeak, 3min 50% HRpeak) over a two-week period. Body mass decreased and VO2peak increased more after INT than CONT (INT:-0.6 ± 0.2 kg, CONT:-0.1 ± 0.2 kg; p = 0.04; INT: 1.9 ± 0.6 mL/kg/min, CONT: 0.1 ± 0.6 mL.kg-1.min-1; p = 0.04). Training increased fat oxidation by 0.7 ± 0.2 mL.kg-1.min-1 during the absolute intensity test (p < 0.001), independent of intensity. During the relative intensity test, fat oxidation increased more after INT than CONT (INT: 1.3 ± 0.4 mL.kg-1.min-1, CONT: 0.3 ± 0.3 mL.kg-1.min-1; p = 0.03), with no difference in exercise energy expenditure between groups. Enhanced fat oxidation during the relative test was correlated with increased VO2peak (r = 0.53 p = 0.01). High intensity INT training enhances fat oxidation during the same relative intensity exercise in people with prediabetes.
AB - Prediabetes is associated with impaired oxidative capacity and altered substrate utilization during exercise. The effects of continuous (CONT) versus interval (INT) exercise training on fat oxidation during an acute exercise bout at the same absolute and relative intensities are unknown in this population. Obese fe-males/males (n = 17, n = 5) with prediabetes (BMI 32.2 ± 1.2 kg.m-2; age 62.8 ± 1.6 y; fasting glucose 103.4 ± 1.6 mg.dL-1; 2-hour glucose 153.7 ± 7.1 mg.dL-1; VO2peak 19.9 ± 1.0 mL.kg-1.min-1) were screened with a 75g OGTT. Subjects completed a peak oxygen consumption test and a submaximal exercise substrate utilization test consisting of 5min stages at absolute (30W) and relative (70%HRpeak) intensities before and after randomiza-tion to 12 sessions (60min each) of CONT (70% HRpeak) or INT (alternating 3min 90% HRpeak, 3min 50% HRpeak) over a two-week period. Body mass decreased and VO2peak increased more after INT than CONT (INT:-0.6 ± 0.2 kg, CONT:-0.1 ± 0.2 kg; p = 0.04; INT: 1.9 ± 0.6 mL/kg/min, CONT: 0.1 ± 0.6 mL.kg-1.min-1; p = 0.04). Training increased fat oxidation by 0.7 ± 0.2 mL.kg-1.min-1 during the absolute intensity test (p < 0.001), independent of intensity. During the relative intensity test, fat oxidation increased more after INT than CONT (INT: 1.3 ± 0.4 mL.kg-1.min-1, CONT: 0.3 ± 0.3 mL.kg-1.min-1; p = 0.03), with no difference in exercise energy expenditure between groups. Enhanced fat oxidation during the relative test was correlated with increased VO2peak (r = 0.53 p = 0.01). High intensity INT training enhances fat oxidation during the same relative intensity exercise in people with prediabetes.
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M3 - Article
C2 - 31827347
AN - SCOPUS:85075313964
SN - 1303-2968
VL - 18
SP - 636
EP - 644
JO - Journal of Sports Science and Medicine
JF - Journal of Sports Science and Medicine
IS - 4
ER -