Type 2 diabetes susceptibility single-nucleotide polymorphisms are not associated with polycystic ovary syndrome

Kathryn G. Ewens; Michelle R. Jones; Wendy Ankener; Douglas R. Stewart; Margrit Urbanek; Andrea Dunaif; Richard S. Legro; Angela Chua; Ricardo Azziz; Richard S. Spielman; Mark O. Goodarzi; Jerome F. Strauss

doi:10.1016/j.fertnstert.2011.02.050

Type 2 diabetes susceptibility single-nucleotide polymorphisms are not associated with polycystic ovary syndrome

Kathryn G. Ewens
, Michelle R. Jones
, Wendy Ankener
, Douglas R. Stewart
, Margrit Urbanek
, Andrea Dunaif
, Richard S. Legro
, Angela Chua
, Ricardo Azziz
, Richard S. Spielman
, Mark O. Goodarzi
, Jerome F. Strauss

Research output: Contribution to journal › Article › peer-review

32 Scopus citations

Abstract

Two cohorts of women with polycystic ovary syndrome (PCOS), comprising 400 probands and affected sisters in 365 families and a case-control group including 395 women with PCOS and 171 healthy women with regular menstrual cycles, were studied to determine whether single-nucleotide polymorphisms (SNPs) identified as susceptibility loci in genomewide association studies of type 2 diabetes are also associated with PCOS. None of the 18 allelic variants in 10 genes previously shown to be associated with type 2 diabetes were found to be associated with PCOS, but some were associated with indices of beta cell function.

Original language	English (US)
Pages (from-to)	2538-2541.e6
Journal	Fertility and sterility
Volume	95
Issue number	8
DOIs	https://doi.org/10.1016/j.fertnstert.2011.02.050
State	Published - Jun 30 2011

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

All Science Journal Classification (ASJC) codes

Reproductive Medicine
Obstetrics and Gynecology

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10.1016/j.fertnstert.2011.02.050

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Ewens, K. G., Jones, M. R., Ankener, W., Stewart, D. R., Urbanek, M., Dunaif, A., Legro, R. S., Chua, A., Azziz, R., Spielman, R. S., Goodarzi, M. O., & Strauss, J. F. (2011). Type 2 diabetes susceptibility single-nucleotide polymorphisms are not associated with polycystic ovary syndrome. Fertility and sterility, 95(8), 2538-2541.e6. https://doi.org/10.1016/j.fertnstert.2011.02.050

@article{30b430c0f0dd4cd8b302895b09f6c1c2,

title = "Type 2 diabetes susceptibility single-nucleotide polymorphisms are not associated with polycystic ovary syndrome",

abstract = "Two cohorts of women with polycystic ovary syndrome (PCOS), comprising 400 probands and affected sisters in 365 families and a case-control group including 395 women with PCOS and 171 healthy women with regular menstrual cycles, were studied to determine whether single-nucleotide polymorphisms (SNPs) identified as susceptibility loci in genomewide association studies of type 2 diabetes are also associated with PCOS. None of the 18 allelic variants in 10 genes previously shown to be associated with type 2 diabetes were found to be associated with PCOS, but some were associated with indices of beta cell function.",

author = "Ewens, \{Kathryn G.\} and Jones, \{Michelle R.\} and Wendy Ankener and Stewart, \{Douglas R.\} and Margrit Urbanek and Andrea Dunaif and Legro, \{Richard S.\} and Angela Chua and Ricardo Azziz and Spielman, \{Richard S.\} and Goodarzi, \{Mark O.\} and Strauss, \{Jerome F.\}",

note = "Funding Information: Supported by National Institutes of Health (NIH) Grants U54HD034449 (to J.F.S. and R.S.S.); Division of Intramural Research of the National Human Genome Research Institute (D.R.S.); P50 HD44405 (A.D.); U54 HD34449 (to M.U. and A.D.); RR10732 and C06 RR016499 [to Pennsylvania State University General Clinical Research Center (GCRC)]; M01 RR00048 (to Northwestern University GCRC); M01 RR10732 and M01 RR02635 (to Brigham and Women{\textquoteright}s Hospital GCRC); R01-HD29364 and K24-HD01346 (to R.A.); R01-DK79888 (to M.O.G.); and M01-RR00425 (General Clinical Research Center Grant from the NCRR ); the Winnick Clinical Scholars Award (to M.O.G.); and an endowment from the Helping Hand of Los Angeles, Inc. Funded in part under a grant with the Pennsylvania Department of Health using Tobacco Settlement Funds (R.S.L.-SAP 41-000-26343). The Department specifically disclaims responsibility for any analyses, interpretations or conclusions. The content of this publication does not necessarily reflect the views or policies of the Department of Health and Human Services, nor does mention of trade names, commercial products or organizations imply endorsement by the U.S. Government. ",

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Ewens, KG, Jones, MR, Ankener, W, Stewart, DR, Urbanek, M, Dunaif, A, Legro, RS, Chua, A, Azziz, R, Spielman, RS, Goodarzi, MO & Strauss, JF 2011, 'Type 2 diabetes susceptibility single-nucleotide polymorphisms are not associated with polycystic ovary syndrome', Fertility and sterility, vol. 95, no. 8, pp. 2538-2541.e6. https://doi.org/10.1016/j.fertnstert.2011.02.050

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AU - Ewens, Kathryn G.

AU - Jones, Michelle R.

AU - Ankener, Wendy

AU - Stewart, Douglas R.

AU - Urbanek, Margrit

AU - Dunaif, Andrea

AU - Legro, Richard S.

AU - Chua, Angela

AU - Azziz, Ricardo

AU - Spielman, Richard S.

AU - Goodarzi, Mark O.

AU - Strauss, Jerome F.

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PY - 2011/6/30

Y1 - 2011/6/30

N2 - Two cohorts of women with polycystic ovary syndrome (PCOS), comprising 400 probands and affected sisters in 365 families and a case-control group including 395 women with PCOS and 171 healthy women with regular menstrual cycles, were studied to determine whether single-nucleotide polymorphisms (SNPs) identified as susceptibility loci in genomewide association studies of type 2 diabetes are also associated with PCOS. None of the 18 allelic variants in 10 genes previously shown to be associated with type 2 diabetes were found to be associated with PCOS, but some were associated with indices of beta cell function.

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JF - Fertility and sterility

IS - 8

ER -

Type 2 diabetes susceptibility single-nucleotide polymorphisms are not associated with polycystic ovary syndrome

Abstract

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