TY - GEN
T1 - UKF-based adaptive electric fields control of desynchronization for the PR model under the ephaptic transmission
AU - Wei, Xile
AU - Cheng, Jian
AU - Wang, Jiang
AU - Deng, Bin
AU - Lu, Meili
AU - Che, Yanqiu
PY - 2012
Y1 - 2012
N2 - The applied electric field (EF) has shown to have great influence on epileptiform firing. Epilepsy is a dynamical disease charactered by hypersynchronous firing. Taking the electrical characteristic of extracellular medium i.e. ephaptic transmission into consideration, we build a PR model in the presence of the applied electric field. V̄ DS out is the DC part of the voltage between soma and dendrite that electric field takes effect on PR neuron. In this paper we find V̄ DS out is the key parameter that affects the neuronal synchronization and use Unscented Kalman Filter (UKF) to estimate it, then based on key parameter we design a closed-loop control to desynchronize neuronal firing. It is found that the control can not only desynchronize neuronal network, but also can adjust the strength of applied electric field according to the degree of synchronization.
AB - The applied electric field (EF) has shown to have great influence on epileptiform firing. Epilepsy is a dynamical disease charactered by hypersynchronous firing. Taking the electrical characteristic of extracellular medium i.e. ephaptic transmission into consideration, we build a PR model in the presence of the applied electric field. V̄ DS out is the DC part of the voltage between soma and dendrite that electric field takes effect on PR neuron. In this paper we find V̄ DS out is the key parameter that affects the neuronal synchronization and use Unscented Kalman Filter (UKF) to estimate it, then based on key parameter we design a closed-loop control to desynchronize neuronal firing. It is found that the control can not only desynchronize neuronal network, but also can adjust the strength of applied electric field according to the degree of synchronization.
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U2 - 10.1109/CCDC.2012.6244389
DO - 10.1109/CCDC.2012.6244389
M3 - Conference contribution
AN - SCOPUS:84866665247
SN - 9781457720727
T3 - Proceedings of the 2012 24th Chinese Control and Decision Conference, CCDC 2012
SP - 2439
EP - 2444
BT - Proceedings of the 2012 24th Chinese Control and Decision Conference, CCDC 2012
T2 - 2012 24th Chinese Control and Decision Conference, CCDC 2012
Y2 - 23 May 2012 through 25 May 2012
ER -