TY - GEN
T1 - UKF-based state feedback control of abnormal neural oscillations in demyelination symptom
AU - Jin, Qitao
AU - Wang, Jiang
AU - Deng, Bin
AU - Wei, Xile
AU - Dong, Feng
AU - Li, Huiyan
AU - Che, Yanqiu
PY - 2012
Y1 - 2012
N2 - Fast axonal conduction of action potentials in mammals relies on myelin insulation. Demyelination can cause slowed, blocked, desynchronized, or paradoxically excessive spiking that underlies the symptoms observed in demyelination diseases. Feedback control via functional electrical stimulation (FES) seems to be a promising treatment modality in such diseases. However, there are challenges to implementing such method for neurons: high nonlinearity, biological tissue constrains and unobservable ion channel states. To address this problem, we propose an estimating and tracking control strategy for systems based on Kalman filter, in order to enhance the action potential propagation reliability of demyelinated neuron via FES. Our method could promote the design of new closed-loop electrical stimulation systems for patients suffering from different nerve system dysfunctions.
AB - Fast axonal conduction of action potentials in mammals relies on myelin insulation. Demyelination can cause slowed, blocked, desynchronized, or paradoxically excessive spiking that underlies the symptoms observed in demyelination diseases. Feedback control via functional electrical stimulation (FES) seems to be a promising treatment modality in such diseases. However, there are challenges to implementing such method for neurons: high nonlinearity, biological tissue constrains and unobservable ion channel states. To address this problem, we propose an estimating and tracking control strategy for systems based on Kalman filter, in order to enhance the action potential propagation reliability of demyelinated neuron via FES. Our method could promote the design of new closed-loop electrical stimulation systems for patients suffering from different nerve system dysfunctions.
UR - http://www.scopus.com/inward/record.url?scp=84872296402&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84872296402&partnerID=8YFLogxK
U2 - 10.1109/WCICA.2012.6359423
DO - 10.1109/WCICA.2012.6359423
M3 - Conference contribution
AN - SCOPUS:84872296402
SN - 9781467313988
T3 - Proceedings of the World Congress on Intelligent Control and Automation (WCICA)
SP - 4984
EP - 4988
BT - WCICA 2012 - Proceedings of the 10th World Congress on Intelligent Control and Automation
T2 - 10th World Congress on Intelligent Control and Automation, WCICA 2012
Y2 - 6 July 2012 through 8 July 2012
ER -