Ultrathin conformal devices for precise and continuous thermal characterization of human skin

R. Chad Webb; Andrew P. Bonifas; Alex Behnaz; Yihui Zhang; Ki Jun Yu; Huanyu Cheng; Mingxing Shi; Zuguang Bian; Zhuangjian Liu; Yun Soung Kim; Woon Hong Yeo; Jae Suk Park; Jizhou Song; Yuhang Li; Yonggang Huang; Alexander M. Gorbach; John A. Rogers

doi:10.1038/nmat3755

Ultrathin conformal devices for precise and continuous thermal characterization of human skin

R. Chad Webb, Andrew P. Bonifas, Alex Behnaz, Yihui Zhang, Ki Jun Yu, Huanyu Cheng, Mingxing Shi, Zuguang Bian, Zhuangjian Liu, Yun Soung Kim, Woon Hong Yeo, Jae Suk Park, Jizhou Song, Yuhang Li, Yonggang Huang, Alexander M. Gorbach, John A. Rogers

Research output: Contribution to journal › Article › peer-review

1039 Scopus citations

Abstract

Precision thermometry of the skin can, together with other measurements, provide clinically relevant information about cardiovascular health, cognitive state, malignancy and many other important aspects of human physiology. Here, we introduce an ultrathin, compliant skin-like sensor/actuator technology that can pliably laminate onto the epidermis to provide continuous, accurate thermal characterizations that are unavailable with other methods. Examples include non-invasive spatial mapping of skin temperature with millikelvin precision, and simultaneous quantitative assessment of tissue thermal conductivity. Such devices can also be implemented in ways that reveal the time-dynamic influence of blood flow and perfusion on these properties. Experimental and theoretical studies establish the underlying principles of operation, and define engineering guidelines for device design. Evaluation of subtle variations in skin temperature associated with mental activity, physical stimulation and vasoconstriction/dilation along with accurate determination of skin hydration through measurements of thermal conductivity represent some important operational examples.

Original language	English (US)
Pages (from-to)	938-944
Number of pages	7
Journal	Nature Materials
Volume	12
Issue number	10
DOIs	https://doi.org/10.1038/nmat3755
State	Published - Oct 2013

All Science Journal Classification (ASJC) codes

General Chemistry
General Materials Science
Condensed Matter Physics
Mechanics of Materials
Mechanical Engineering

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1038/nmat3755

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Webb, R. C., Bonifas, A. P., Behnaz, A., Zhang, Y., Yu, K. J., Cheng, H., Shi, M., Bian, Z., Liu, Z., Kim, Y. S., Yeo, W. H., Park, J. S., Song, J., Li, Y., Huang, Y., Gorbach, A. M., & Rogers, J. A. (2013). Ultrathin conformal devices for precise and continuous thermal characterization of human skin. Nature Materials, 12(10), 938-944. https://doi.org/10.1038/nmat3755

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title = "Ultrathin conformal devices for precise and continuous thermal characterization of human skin",

abstract = "Precision thermometry of the skin can, together with other measurements, provide clinically relevant information about cardiovascular health, cognitive state, malignancy and many other important aspects of human physiology. Here, we introduce an ultrathin, compliant skin-like sensor/actuator technology that can pliably laminate onto the epidermis to provide continuous, accurate thermal characterizations that are unavailable with other methods. Examples include non-invasive spatial mapping of skin temperature with millikelvin precision, and simultaneous quantitative assessment of tissue thermal conductivity. Such devices can also be implemented in ways that reveal the time-dynamic influence of blood flow and perfusion on these properties. Experimental and theoretical studies establish the underlying principles of operation, and define engineering guidelines for device design. Evaluation of subtle variations in skin temperature associated with mental activity, physical stimulation and vasoconstriction/dilation along with accurate determination of skin hydration through measurements of thermal conductivity represent some important operational examples.",

author = "Webb, {R. Chad} and Bonifas, {Andrew P.} and Alex Behnaz and Yihui Zhang and Yu, {Ki Jun} and Huanyu Cheng and Mingxing Shi and Zuguang Bian and Zhuangjian Liu and Kim, {Yun Soung} and Yeo, {Woon Hong} and Park, {Jae Suk} and Jizhou Song and Yuhang Li and Yonggang Huang and Gorbach, {Alexander M.} and Rogers, {John A.}",

note = "Funding Information: This material is based on work supported by the National Science Foundation under Grant No. DGE-1144245, Grant No. ECCS-0824129 and through the Materials Research Laboratory and Center for Microanalysis of Materials at the University of Illinois at Urbana-Champaign. J.A.R. acknowledges financial support through a National Security Science and Engineering Faculty Fellowship. The work on silicon nanomembranes was financially supported by a MURI grant from the Air Force Office of Scientific Research. This research was supported in part by the Intramural Research Program of NIBIB, NIH. The authors would like to thank H. Eden for his invaluable critique and insightful comments during preparation of this manuscript.",

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AU - Webb, R. Chad

AU - Bonifas, Andrew P.

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AU - Yu, Ki Jun

AU - Cheng, Huanyu

AU - Shi, Mingxing

AU - Bian, Zuguang

AU - Liu, Zhuangjian

AU - Kim, Yun Soung

AU - Yeo, Woon Hong

AU - Park, Jae Suk

AU - Song, Jizhou

AU - Li, Yuhang

AU - Huang, Yonggang

AU - Gorbach, Alexander M.

AU - Rogers, John A.

N1 - Funding Information: This material is based on work supported by the National Science Foundation under Grant No. DGE-1144245, Grant No. ECCS-0824129 and through the Materials Research Laboratory and Center for Microanalysis of Materials at the University of Illinois at Urbana-Champaign. J.A.R. acknowledges financial support through a National Security Science and Engineering Faculty Fellowship. The work on silicon nanomembranes was financially supported by a MURI grant from the Air Force Office of Scientific Research. This research was supported in part by the Intramural Research Program of NIBIB, NIH. The authors would like to thank H. Eden for his invaluable critique and insightful comments during preparation of this manuscript.

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N2 - Precision thermometry of the skin can, together with other measurements, provide clinically relevant information about cardiovascular health, cognitive state, malignancy and many other important aspects of human physiology. Here, we introduce an ultrathin, compliant skin-like sensor/actuator technology that can pliably laminate onto the epidermis to provide continuous, accurate thermal characterizations that are unavailable with other methods. Examples include non-invasive spatial mapping of skin temperature with millikelvin precision, and simultaneous quantitative assessment of tissue thermal conductivity. Such devices can also be implemented in ways that reveal the time-dynamic influence of blood flow and perfusion on these properties. Experimental and theoretical studies establish the underlying principles of operation, and define engineering guidelines for device design. Evaluation of subtle variations in skin temperature associated with mental activity, physical stimulation and vasoconstriction/dilation along with accurate determination of skin hydration through measurements of thermal conductivity represent some important operational examples.

AB - Precision thermometry of the skin can, together with other measurements, provide clinically relevant information about cardiovascular health, cognitive state, malignancy and many other important aspects of human physiology. Here, we introduce an ultrathin, compliant skin-like sensor/actuator technology that can pliably laminate onto the epidermis to provide continuous, accurate thermal characterizations that are unavailable with other methods. Examples include non-invasive spatial mapping of skin temperature with millikelvin precision, and simultaneous quantitative assessment of tissue thermal conductivity. Such devices can also be implemented in ways that reveal the time-dynamic influence of blood flow and perfusion on these properties. Experimental and theoretical studies establish the underlying principles of operation, and define engineering guidelines for device design. Evaluation of subtle variations in skin temperature associated with mental activity, physical stimulation and vasoconstriction/dilation along with accurate determination of skin hydration through measurements of thermal conductivity represent some important operational examples.

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Ultrathin conformal devices for precise and continuous thermal characterization of human skin

Abstract

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