Understanding associative false memories in aging using multivariate analyses

Age-related declines in associative memory are ubiquitous, with decreases in behavioral discriminability largely arising from increases in false memories for recombined lures. Using representational similarity analyses to examine the neural basis of associative false memories in aging, the current study found that neural pattern similarity between Hits and FAs and Hits and CRs differed as a function of age in occipital ROIs, such that older adults exhibited a smaller difference between the two similarity metrics than did younger adults. Additionally, greater Hit-FA representational similarity correlated with increases in associative FAs across several ROIs. Results suggest that while neural representations underlying targets may not differ across ages, greater pattern similarity between the neural representation of targets and lures may reflect reduced distinctiveness of the information encoded in memory, such that old and new items are more difficult to discriminate, leading to more false alarms.