TY - JOUR
T1 - Understanding conserved amino acids in proteins
AU - Dokholyan, Nikolay
AU - Mirny, Leonid A.
AU - Shakhnovich, Eugene I.
N1 - Funding Information:
We thank R.S. Dokholyan for careful reading of the manuscript and H. Angerman and S.V. Buldyrev for helpful discussions. NVD is supported by NIH postdoctoral fellowship (GM20251-01). EIS is supported by NIH.
PY - 2002
Y1 - 2002
N2 - It has been conjectured that evolution exerted pressure to preserve amino acids bearing thermodynamic, kinetic, and functional roles. In this letter we show that the physical requirement to maintain protein stability gives rise to a sequence conservatism pattern that is in remarkable agreement with that found in natural proteins. Based on the physical properties of amino acids, we propose a model of evolution that explains conserved amino acids across protein families sharing the same fold.
AB - It has been conjectured that evolution exerted pressure to preserve amino acids bearing thermodynamic, kinetic, and functional roles. In this letter we show that the physical requirement to maintain protein stability gives rise to a sequence conservatism pattern that is in remarkable agreement with that found in natural proteins. Based on the physical properties of amino acids, we propose a model of evolution that explains conserved amino acids across protein families sharing the same fold.
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U2 - 10.1016/S0378-4371(02)01079-8
DO - 10.1016/S0378-4371(02)01079-8
M3 - Article
AN - SCOPUS:0036950560
SN - 0378-4371
VL - 314
SP - 600
EP - 606
JO - Physica A: Statistical Mechanics and its Applications
JF - Physica A: Statistical Mechanics and its Applications
IS - 1-4
ER -