Understanding DNA replication by the bacteriophage T4 replisome

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The T4 replisome has provided a unique opportunity to investigate the intricacies of DNA replication. We present a comprehensive review of this system focusing on the following: its 8-protein composition, their individual and synergistic activities, and assembly in vitro and in vivo into a replisome capable of coordinated leading/lagging strand DNA synthesis. We conclude with a brief comparison with other replisomes with emphasis on how coordinated DNA replication is achieved.

Original languageEnglish (US)
Pages (from-to)18434-18442
Number of pages9
JournalJournal of Biological Chemistry
Issue number45
StatePublished - Nov 10 2017

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Cell Biology


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