TY - JOUR
T1 - Understanding DNA replication by the bacteriophage T4 replisome
AU - Benkovic, Stephen J.
AU - Spiering, Michelle M.
N1 - Publisher Copyright:
© 2017 by The American Society for Biochemistry and Molecular Biology, Inc.
PY - 2017/11/10
Y1 - 2017/11/10
N2 - The T4 replisome has provided a unique opportunity to investigate the intricacies of DNA replication. We present a comprehensive review of this system focusing on the following: its 8-protein composition, their individual and synergistic activities, and assembly in vitro and in vivo into a replisome capable of coordinated leading/lagging strand DNA synthesis. We conclude with a brief comparison with other replisomes with emphasis on how coordinated DNA replication is achieved.
AB - The T4 replisome has provided a unique opportunity to investigate the intricacies of DNA replication. We present a comprehensive review of this system focusing on the following: its 8-protein composition, their individual and synergistic activities, and assembly in vitro and in vivo into a replisome capable of coordinated leading/lagging strand DNA synthesis. We conclude with a brief comparison with other replisomes with emphasis on how coordinated DNA replication is achieved.
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U2 - 10.1074/jbc.R117.811208
DO - 10.1074/jbc.R117.811208
M3 - Review article
C2 - 28972188
AN - SCOPUS:85033579630
SN - 0021-9258
VL - 292
SP - 18434
EP - 18442
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
IS - 45
ER -