Abstract
The T4 replisome has provided a unique opportunity to investigate the intricacies of DNA replication. We present a comprehensive review of this system focusing on the following: its 8-protein composition, their individual and synergistic activities, and assembly in vitro and in vivo into a replisome capable of coordinated leading/lagging strand DNA synthesis. We conclude with a brief comparison with other replisomes with emphasis on how coordinated DNA replication is achieved.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 18434-18442 |
| Number of pages | 9 |
| Journal | Journal of Biological Chemistry |
| Volume | 292 |
| Issue number | 45 |
| DOIs | |
| State | Published - Nov 10 2017 |
All Science Journal Classification (ASJC) codes
- Biochemistry
- Molecular Biology
- Cell Biology
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