Understanding Herd Immunity

C. J.E. Metcalf; M. Ferrari; A. L. Graham; B. T. Grenfell

doi:10.1016/j.it.2015.10.004

Understanding Herd Immunity

C. J.E. Metcalf, M. Ferrari, A. L. Graham, B. T. Grenfell

Research output: Contribution to journal › Comment/debate › peer-review

107 Scopus citations

Abstract

Individual immunity is a powerful force affecting host health and pathogen evolution. Importantly, the effects of individual immunity also scale up to affect pathogen transmission dynamics and the success of vaccination campaigns for entire host populations. Popu- lation-scale immunity is often termed 'herd immunity'. Here we outline how individual immunity maps to population outcomes and discuss implications for control of infectious diseases. Particu- lar immunological characteristics may be more or less likely to result in a population level signature of herd immunity; we detail this and also discuss other population-level outcomes that might emerge from individual-level immunity.

Original language	English (US)
Pages (from-to)	753-755
Number of pages	3
Journal	Trends in Immunology
Volume	36
Issue number	12
DOIs	https://doi.org/10.1016/j.it.2015.10.004
State	Published - Dec 1 2015

All Science Journal Classification (ASJC) codes

Immunology and Allergy
Immunology

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abstract = "Individual immunity is a powerful force affecting host health and pathogen evolution. Importantly, the effects of individual immunity also scale up to affect pathogen transmission dynamics and the success of vaccination campaigns for entire host populations. Popu- lation-scale immunity is often termed 'herd immunity'. Here we outline how individual immunity maps to population outcomes and discuss implications for control of infectious diseases. Particu- lar immunological characteristics may be more or less likely to result in a population level signature of herd immunity; we detail this and also discuss other population-level outcomes that might emerge from individual-level immunity.",

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AU - Ferrari, M.

AU - Graham, A. L.

AU - Grenfell, B. T.

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N2 - Individual immunity is a powerful force affecting host health and pathogen evolution. Importantly, the effects of individual immunity also scale up to affect pathogen transmission dynamics and the success of vaccination campaigns for entire host populations. Popu- lation-scale immunity is often termed 'herd immunity'. Here we outline how individual immunity maps to population outcomes and discuss implications for control of infectious diseases. Particu- lar immunological characteristics may be more or less likely to result in a population level signature of herd immunity; we detail this and also discuss other population-level outcomes that might emerge from individual-level immunity.

AB - Individual immunity is a powerful force affecting host health and pathogen evolution. Importantly, the effects of individual immunity also scale up to affect pathogen transmission dynamics and the success of vaccination campaigns for entire host populations. Popu- lation-scale immunity is often termed 'herd immunity'. Here we outline how individual immunity maps to population outcomes and discuss implications for control of infectious diseases. Particu- lar immunological characteristics may be more or less likely to result in a population level signature of herd immunity; we detail this and also discuss other population-level outcomes that might emerge from individual-level immunity.

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Understanding Herd Immunity

Abstract

All Science Journal Classification (ASJC) codes

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