TY - JOUR
T1 - Understanding the host in the management of pneumonia
T2 - An official American thoracic society workshop report
AU - American Thoracic Society Assembly on Pulmonary Infection and Tuberculosis
AU - Dela Cruz, Charles S.
AU - Wunderink, Richard G.
AU - Amara-Elori, Isabel
AU - Awasthi, Shanjana
AU - Caler, Elisabet
AU - Cao, Bin
AU - Chalmers, James D.
AU - Chastre, Jean
AU - Cohen, Alan H.
AU - Cohen, Taylor S.
AU - Crothers, Kristina
AU - Peter Di, Y.
AU - Dean, Nathan
AU - Egan, Marie E.
AU - Evans, Scott E.
AU - Feldman, Charles
AU - Gautam, Samir
AU - Halstead, E. Scott
AU - Herold, Susanne
AU - Jones, Barbara E.
AU - Luna, Carlos
AU - Mendez, Raul
AU - Menendez, Rosario
AU - Mizgerd, Joseph P.
AU - Niederman, Michael S.
AU - Nusrat, Roomi
AU - Ramirez, Julio
AU - Restrepo, Marcos I.
AU - Shindo, Yuichiro
AU - Stevens, Chris
AU - Torres, Antonio
AU - Waterer, Grant
AU - Yeligar, Samantha M.
N1 - Publisher Copyright:
Copyright © 2021 by the American Thoracic Society
PY - 2021/7
Y1 - 2021/7
N2 - Pneumonia causes a significant burden of disease worldwide. Although all populations are at risk of pneumonia, those at extremes of age and those with immunosuppressive disorders, underlying respiratory disease, and critical illness are particularly vulnerable. Although clinical practice guidelines addressing the management and treatment of pneumonia exist, few of the supporting studies focus on the crucial contributions of the host in pneumonia pathogenesis and recovery. Such essential considerations include the host risk factors that lead to susceptibility to lung infections; biomarkers reflecting the host response and the means to pursue host-directed pneumonia therapy; systemic effects of pneumonia on the host; and long-term health outcomes after pneumonia. To address these gaps, the Pneumonia Working Group of the Assembly on Pulmonary Infection and Tuberculosis led a workshop held at the American Thoracic Society meeting in May 2018 with overarching objectives to foster attention, stimulate research, and promote funding for short-term and long-term investigations into the host contributions to pneumonia. The workshop involved participants from various disciplines with expertise in lung infection, pneumonia, sepsis, immunocompromised patients, translational biology, data science, genomics, systems biology, and clinical trials. This workshop report summarizes the presentations and discussions and important recommendations for future clinical pneumonia studies. These recommendations include establishing consensus disease and outcome definitions, improved phenotyping, development of clinical study networks, standardized data and biospecimen collection and protocols, and development of innovative trial designs.
AB - Pneumonia causes a significant burden of disease worldwide. Although all populations are at risk of pneumonia, those at extremes of age and those with immunosuppressive disorders, underlying respiratory disease, and critical illness are particularly vulnerable. Although clinical practice guidelines addressing the management and treatment of pneumonia exist, few of the supporting studies focus on the crucial contributions of the host in pneumonia pathogenesis and recovery. Such essential considerations include the host risk factors that lead to susceptibility to lung infections; biomarkers reflecting the host response and the means to pursue host-directed pneumonia therapy; systemic effects of pneumonia on the host; and long-term health outcomes after pneumonia. To address these gaps, the Pneumonia Working Group of the Assembly on Pulmonary Infection and Tuberculosis led a workshop held at the American Thoracic Society meeting in May 2018 with overarching objectives to foster attention, stimulate research, and promote funding for short-term and long-term investigations into the host contributions to pneumonia. The workshop involved participants from various disciplines with expertise in lung infection, pneumonia, sepsis, immunocompromised patients, translational biology, data science, genomics, systems biology, and clinical trials. This workshop report summarizes the presentations and discussions and important recommendations for future clinical pneumonia studies. These recommendations include establishing consensus disease and outcome definitions, improved phenotyping, development of clinical study networks, standardized data and biospecimen collection and protocols, and development of innovative trial designs.
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U2 - 10.1513/AnnalsATS.202102-209ST
DO - 10.1513/AnnalsATS.202102-209ST
M3 - Article
C2 - 34242148
AN - SCOPUS:85109628987
SN - 2329-6933
VL - 18
SP - 1087
EP - 1097
JO - Annals of the American Thoracic Society
JF - Annals of the American Thoracic Society
IS - 7
ER -