Unnatural translation initiation

John W. Tomsho, Stephen J. Benkovic

Research output: Contribution to journalArticlepeer-review


Protein translation in nature always begins with an initiator transfer RNA (tRNA) carrying the amino acid methionine. This was circumvented in vitro with a reconstituted translation system utilizing initiator tRNA synthetically mischarged with the other natural amino acids. In addition, it was determined that this system could accommodate these non-methionine amino acids containing various N-α-acyl groups, many of which are useful for post-translational modification such as peptide cyclization.

Original languageEnglish (US)
Pages (from-to)87-88
Number of pages2
JournalACS chemical biology
Issue number2
StatePublished - Feb 2008

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine


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