Unraveling the complexities of ApiAP2 regulation in Plasmodium falciparum

Ritwik Singhal, Isadora O. Prata, Victoria A. Bonnell, Manuel Llinás

Research output: Contribution to journalReview articlepeer-review

Abstract

The regulation of gene expression in Plasmodium spp., the causative agents of malaria, relies on precise transcriptional control. Malaria parasites encode a limited repertoire of sequence-specific transcriptional regulators dominated by the apicomplexan APETALA 2 (ApiAP2) protein family. ApiAP2 DNA-binding proteins play critical roles at all stages of the parasite life cycle. Recent studies have provided mechanistic insight into the functional roles of many ApiAP2 proteins. Two major areas that have advanced significantly are the identification of ApiAP2-containing protein complexes and the role of ApiAP2 proteins in malaria parasite sexual development. In this review, we present recent advances on the functional biology of ApiAP2 proteins and their role in regulating gene expression across the blood stages of the parasite life cycle.

Original languageEnglish (US)
Pages (from-to)987-999
Number of pages13
JournalTrends in Parasitology
Volume40
Issue number11
DOIs
StatePublished - Nov 2024

All Science Journal Classification (ASJC) codes

  • Parasitology
  • Infectious Diseases

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