Unraveling the genomic complexity of sylvatic mosquitoes in changing Neotropical environments

Jose R. Loaiza, Kelly L. Bennett, Matthew J. Miller, Luis F. De León

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


Sylvatic New World mosquitoes (e.g. Old-growth Forest species) can transmit viruses among non-human primates. This could be a continuous source of viral cycling and spillover events from animals to humans, particularly in changing environments. However, most species of Neotropical sylvatic mosquitoes (genera Aedes, Haemagogus, and Sabethes), which include vector and non-vector species, currently lack genomic resources because there is no reliable and accurate approach for creating de novo reference genomes for these insects. This is a major knowledge gap in the biology of these mosquitoes, restricting our ability to predict and mitigate the emergence and spread of novel arboviruses in Neotropical regions. We discuss recent advances and potential solutions for generating hybrid de novo assemblies from vector and non-vector species using pools of consanguineous offspring. We also discussed research opportunities likely to emerge from these genomic resources.

Original languageEnglish (US)
Article number102944
JournalCurrent Opinion in Biotechnology
StatePublished - Jun 2023

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Bioengineering
  • Biomedical Engineering

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