Unrelated umbilical cord stem cell transplantation for X-linked immunodeficiencies

Ulrike H.M. Ziegner; Hans D. Ochs; Carolyn Schanen; Stephen A. Feig; Kuniaki Seyama; Takeshi Futatani; Thomas Gross; Mary Wakim; Robert L. Roberts; David J. Rawlings; Sinisa Dovat; John K. Fraser; E. Richard Stiehm

doi:10.1067/mpd.2001.112511

Unrelated umbilical cord stem cell transplantation for X-linked immunodeficiencies

Ulrike H.M. Ziegner, Hans D. Ochs, Carolyn Schanen, Stephen A. Feig, Kuniaki Seyama, Takeshi Futatani, Thomas Gross, Mary Wakim, Robert L. Roberts, David J. Rawlings, Sinisa Dovat, John K. Fraser, E. Richard Stiehm

Research output: Contribution to journal › Article › peer-review

51 Scopus citations

Abstract

Banked unrelated umbilical cord blood matched at 5 of 6 human leukocyte antigen loci was used to reconstitute the immune system in 2 brothers with X-linked lymphoproliferative syndrome and 1 boy with X-linked hyperimmunoglobulin-M syndrome. Pretransplant cytoreduction and post-transplant graft-versus-host prophylaxis were given. Hematopoietic engraftment and correction of the genetic defects were documented by molecular techniques. Two years after transplantation, all 3 patients have normal immune systems. These reports support the wider use of banked partially matched cord blood for transplantation in primary immunodeficiencies.

Original language	English (US)
Pages (from-to)	570-573
Number of pages	4
Journal	Journal of Pediatrics
Volume	138
Issue number	4
DOIs	https://doi.org/10.1067/mpd.2001.112511
State	Published - 2001

All Science Journal Classification (ASJC) codes

Pediatrics, Perinatology, and Child Health

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10.1067/mpd.2001.112511

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title = "Unrelated umbilical cord stem cell transplantation for X-linked immunodeficiencies",

abstract = "Banked unrelated umbilical cord blood matched at 5 of 6 human leukocyte antigen loci was used to reconstitute the immune system in 2 brothers with X-linked lymphoproliferative syndrome and 1 boy with X-linked hyperimmunoglobulin-M syndrome. Pretransplant cytoreduction and post-transplant graft-versus-host prophylaxis were given. Hematopoietic engraftment and correction of the genetic defects were documented by molecular techniques. Two years after transplantation, all 3 patients have normal immune systems. These reports support the wider use of banked partially matched cord blood for transplantation in primary immunodeficiencies.",

author = "Ziegner, {Ulrike H.M.} and Ochs, {Hans D.} and Carolyn Schanen and Feig, {Stephen A.} and Kuniaki Seyama and Takeshi Futatani and Thomas Gross and Mary Wakim and Roberts, {Robert L.} and Rawlings, {David J.} and Sinisa Dovat and Fraser, {John K.} and Stiehm, {E. Richard}",

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doi = "10.1067/mpd.2001.112511",

language = "English (US)",

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T1 - Unrelated umbilical cord stem cell transplantation for X-linked immunodeficiencies

AU - Ziegner, Ulrike H.M.

AU - Ochs, Hans D.

AU - Schanen, Carolyn

AU - Feig, Stephen A.

AU - Seyama, Kuniaki

AU - Futatani, Takeshi

AU - Gross, Thomas

AU - Wakim, Mary

AU - Roberts, Robert L.

AU - Rawlings, David J.

AU - Dovat, Sinisa

AU - Fraser, John K.

AU - Stiehm, E. Richard

PY - 2001

Y1 - 2001

N2 - Banked unrelated umbilical cord blood matched at 5 of 6 human leukocyte antigen loci was used to reconstitute the immune system in 2 brothers with X-linked lymphoproliferative syndrome and 1 boy with X-linked hyperimmunoglobulin-M syndrome. Pretransplant cytoreduction and post-transplant graft-versus-host prophylaxis were given. Hematopoietic engraftment and correction of the genetic defects were documented by molecular techniques. Two years after transplantation, all 3 patients have normal immune systems. These reports support the wider use of banked partially matched cord blood for transplantation in primary immunodeficiencies.

AB - Banked unrelated umbilical cord blood matched at 5 of 6 human leukocyte antigen loci was used to reconstitute the immune system in 2 brothers with X-linked lymphoproliferative syndrome and 1 boy with X-linked hyperimmunoglobulin-M syndrome. Pretransplant cytoreduction and post-transplant graft-versus-host prophylaxis were given. Hematopoietic engraftment and correction of the genetic defects were documented by molecular techniques. Two years after transplantation, all 3 patients have normal immune systems. These reports support the wider use of banked partially matched cord blood for transplantation in primary immunodeficiencies.

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Unrelated umbilical cord stem cell transplantation for X-linked immunodeficiencies

Abstract

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