Updates on GMSCs Treatment for Autoimmune Diseases

Feng Huang; Zhong Ming Liu; Song Guo Zheng

doi:10.2174/1574888X13666180220141114

Updates on GMSCs Treatment for Autoimmune Diseases

Feng Huang, Zhong Ming Liu, Song Guo Zheng

Department of Medicine

Research output: Contribution to journal › Review article › peer-review

17 Scopus citations

Abstract

Background: Autoimmune disease is a refractory disease. Accumulating Evidence has revealed that the manipulation of mesenchymal stem cells may have the potential to control or even treat autoimmune diseases. Human gingiva-derived mesenchymal stem cells (GMSCs) are emerging as a new line of mesenchymal stem cells that have displayed some potential advantages in controlling and treating autoimmune diseases. Objective: In this review, we briefly update the current understanding on the biology of GMSCs and their effects on preventing and treating autoimmune diseases. Conclusion: The availability of gingival mesenchymal stem cells (GMSCs), together with their potent capacity of multi-directional differentiation and inflammatory modulation, making GMSCs an ideal subtype of MSCs in treating autoimmune disease. Our and other studies have launched the earliest appraisal on GMSCs and carried out a lot of biological researches. The clinical trial of GMSCs on patients with autoimmune diseases will further approve their therapeutic effects, as well as its cellular and molecular mechanisms.

Original language	English (US)
Pages (from-to)	345-349
Number of pages	5
Journal	Current Stem Cell Research and Therapy
Volume	13
Issue number	5
DOIs	https://doi.org/10.2174/1574888X13666180220141114
State	Published - 2018

All Science Journal Classification (ASJC) codes

Medicine (miscellaneous)

Access to Document

10.2174/1574888X13666180220141114

Cite this

@article{aa446e25d0624015ad81841267151dd0,

title = "Updates on GMSCs Treatment for Autoimmune Diseases",

abstract = "Background: Autoimmune disease is a refractory disease. Accumulating Evidence has revealed that the manipulation of mesenchymal stem cells may have the potential to control or even treat autoimmune diseases. Human gingiva-derived mesenchymal stem cells (GMSCs) are emerging as a new line of mesenchymal stem cells that have displayed some potential advantages in controlling and treating autoimmune diseases. Objective: In this review, we briefly update the current understanding on the biology of GMSCs and their effects on preventing and treating autoimmune diseases. Conclusion: The availability of gingival mesenchymal stem cells (GMSCs), together with their potent capacity of multi-directional differentiation and inflammatory modulation, making GMSCs an ideal subtype of MSCs in treating autoimmune disease. Our and other studies have launched the earliest appraisal on GMSCs and carried out a lot of biological researches. The clinical trial of GMSCs on patients with autoimmune diseases will further approve their therapeutic effects, as well as its cellular and molecular mechanisms.",

author = "Feng Huang and Liu, {Zhong Ming} and Zheng, {Song Guo}",

note = "Funding Information: This review was partially supported by the National Key R & D Program of China (2017YFA0105801), the Natural Science Foundation of Guangdong Province of China (2014A030308005), the Science and Technology Program of Guangzhou of China (Special Project on the Integration of Industry, Education and Research) (201508020060), the Guangdong Introducing Innovative and Entrepreneurial Teams (2016ZT06S252), and the NIH AR073409. Funding Information: This review was partially supported by the National Key R&D Program of China (2017YFA0105801), the Natural Science Foundation of Guangdong Province of China (2014A030308005), the Science and Technology Program of Guangzhou of China (Special Project on the Integration of Industry, Education and Research) (201508020060), the Guangdong Introducing Innovative and Entrepreneurial Teams (2016ZT06S252), and the NIH AR073409. Publisher Copyright: {\textcopyright} 2018 Bentham Science Publishers.",

year = "2018",

doi = "10.2174/1574888X13666180220141114",

language = "English (US)",

volume = "13",

pages = "345--349",

journal = "Current Stem Cell Research and Therapy",

issn = "1574-888X",

publisher = "Bentham Science Publishers",

number = "5",

}

TY - JOUR

T1 - Updates on GMSCs Treatment for Autoimmune Diseases

AU - Huang, Feng

AU - Liu, Zhong Ming

AU - Zheng, Song Guo

N1 - Funding Information: This review was partially supported by the National Key R & D Program of China (2017YFA0105801), the Natural Science Foundation of Guangdong Province of China (2014A030308005), the Science and Technology Program of Guangzhou of China (Special Project on the Integration of Industry, Education and Research) (201508020060), the Guangdong Introducing Innovative and Entrepreneurial Teams (2016ZT06S252), and the NIH AR073409. Funding Information: This review was partially supported by the National Key R&D Program of China (2017YFA0105801), the Natural Science Foundation of Guangdong Province of China (2014A030308005), the Science and Technology Program of Guangzhou of China (Special Project on the Integration of Industry, Education and Research) (201508020060), the Guangdong Introducing Innovative and Entrepreneurial Teams (2016ZT06S252), and the NIH AR073409. Publisher Copyright: © 2018 Bentham Science Publishers.

PY - 2018

Y1 - 2018

N2 - Background: Autoimmune disease is a refractory disease. Accumulating Evidence has revealed that the manipulation of mesenchymal stem cells may have the potential to control or even treat autoimmune diseases. Human gingiva-derived mesenchymal stem cells (GMSCs) are emerging as a new line of mesenchymal stem cells that have displayed some potential advantages in controlling and treating autoimmune diseases. Objective: In this review, we briefly update the current understanding on the biology of GMSCs and their effects on preventing and treating autoimmune diseases. Conclusion: The availability of gingival mesenchymal stem cells (GMSCs), together with their potent capacity of multi-directional differentiation and inflammatory modulation, making GMSCs an ideal subtype of MSCs in treating autoimmune disease. Our and other studies have launched the earliest appraisal on GMSCs and carried out a lot of biological researches. The clinical trial of GMSCs on patients with autoimmune diseases will further approve their therapeutic effects, as well as its cellular and molecular mechanisms.

AB - Background: Autoimmune disease is a refractory disease. Accumulating Evidence has revealed that the manipulation of mesenchymal stem cells may have the potential to control or even treat autoimmune diseases. Human gingiva-derived mesenchymal stem cells (GMSCs) are emerging as a new line of mesenchymal stem cells that have displayed some potential advantages in controlling and treating autoimmune diseases. Objective: In this review, we briefly update the current understanding on the biology of GMSCs and their effects on preventing and treating autoimmune diseases. Conclusion: The availability of gingival mesenchymal stem cells (GMSCs), together with their potent capacity of multi-directional differentiation and inflammatory modulation, making GMSCs an ideal subtype of MSCs in treating autoimmune disease. Our and other studies have launched the earliest appraisal on GMSCs and carried out a lot of biological researches. The clinical trial of GMSCs on patients with autoimmune diseases will further approve their therapeutic effects, as well as its cellular and molecular mechanisms.

UR - http://www.scopus.com/inward/record.url?scp=85048958516&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85048958516&partnerID=8YFLogxK

U2 - 10.2174/1574888X13666180220141114

DO - 10.2174/1574888X13666180220141114

M3 - Review article

C2 - 29468980

AN - SCOPUS:85048958516

SN - 1574-888X

VL - 13

SP - 345

EP - 349

JO - Current Stem Cell Research and Therapy

JF - Current Stem Cell Research and Therapy

IS - 5

ER -

Updates on GMSCs Treatment for Autoimmune Diseases

Abstract

All Science Journal Classification (ASJC) codes

Access to Document

Other files and links

Fingerprint

Cite this