Updating the role of FDG PET/CT for evaluation of lung cancer manifesting in nonsolid nodules

Ying Liu, David F. Yankelevitz, Lale Kostakoglu, Mary B. Beasley, Yu Htwe, Mary M. Salvatore, Rowena Yip, Claudia I. Henschke

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


Purpose: To assess the feasibility of using CT to correct specific uptake values (SUVs) for fluorodeoxyglucose (FDG) in patients with nonsolid nodules. Methods: Patients with FDG-PET/CT and thin-section CT were included in this pilot study. Thirty-five adenocarcinomas manifesting as nonsolid nodules were classified into two groups; 90–100% and 1–89% lepidic component. SUVmax was corrected based on the CT determination of the proportion of soft tissue component within the cancer (SUVatt). Results: Both SUVmax and SUVatt increased as the percentage of the lepidic component decreased. SUVmax and SUVatt were significantly different between the groups. Conclusion: Extent of invasiveness of nonsolid cancers (as a marker of aggressiveness) can potentially be quantified by PET/CT using a correction method that accounts for the proportion of soft tissue within the tumor.

Original languageEnglish (US)
Pages (from-to)157-162
Number of pages6
JournalClinical Imaging
StatePublished - Nov 1 2018

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging


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