Abstract
Purpose: To assess the feasibility of using CT to correct specific uptake values (SUVs) for fluorodeoxyglucose (FDG) in patients with nonsolid nodules. Methods: Patients with FDG-PET/CT and thin-section CT were included in this pilot study. Thirty-five adenocarcinomas manifesting as nonsolid nodules were classified into two groups; 90–100% and 1–89% lepidic component. SUVmax was corrected based on the CT determination of the proportion of soft tissue component within the cancer (SUVatt). Results: Both SUVmax and SUVatt increased as the percentage of the lepidic component decreased. SUVmax and SUVatt were significantly different between the groups. Conclusion: Extent of invasiveness of nonsolid cancers (as a marker of aggressiveness) can potentially be quantified by PET/CT using a correction method that accounts for the proportion of soft tissue within the tumor.
Original language | English (US) |
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Pages (from-to) | 157-162 |
Number of pages | 6 |
Journal | Clinical Imaging |
Volume | 52 |
DOIs | |
State | Published - Nov 1 2018 |
All Science Journal Classification (ASJC) codes
- Radiology Nuclear Medicine and imaging