Updating the role of FDG PET/CT for evaluation of lung cancer manifesting in nonsolid nodules

Ying Liu; David F. Yankelevitz; Lale Kostakoglu; Mary B. Beasley; Yu Htwe; Mary M. Salvatore; Rowena Yip; Claudia I. Henschke

doi:10.1016/j.clinimag.2018.07.004

Updating the role of FDG PET/CT for evaluation of lung cancer manifesting in nonsolid nodules

Ying Liu
, David F. Yankelevitz
, Lale Kostakoglu
, Mary B. Beasley
, Yu Htwe
, Mary M. Salvatore
, Rowena Yip
, Claudia I. Henschke

Department of Medicine

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Purpose: To assess the feasibility of using CT to correct specific uptake values (SUVs) for fluorodeoxyglucose (FDG) in patients with nonsolid nodules. Methods: Patients with FDG-PET/CT and thin-section CT were included in this pilot study. Thirty-five adenocarcinomas manifesting as nonsolid nodules were classified into two groups; 90–100% and 1–89% lepidic component. SUVmax was corrected based on the CT determination of the proportion of soft tissue component within the cancer (SUVatt). Results: Both SUVmax and SUVatt increased as the percentage of the lepidic component decreased. SUVmax and SUVatt were significantly different between the groups. Conclusion: Extent of invasiveness of nonsolid cancers (as a marker of aggressiveness) can potentially be quantified by PET/CT using a correction method that accounts for the proportion of soft tissue within the tumor.

Original language	English (US)
Pages (from-to)	157-162
Number of pages	6
Journal	Clinical Imaging
Volume	52
DOIs	https://doi.org/10.1016/j.clinimag.2018.07.004
State	Published - Nov 1 2018

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

All Science Journal Classification (ASJC) codes

Radiology Nuclear Medicine and imaging

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10.1016/j.clinimag.2018.07.004

Cite this

@article{8abac9fca5034653b89b354e523bc3fc,

title = "Updating the role of FDG PET/CT for evaluation of lung cancer manifesting in nonsolid nodules",

abstract = "Purpose: To assess the feasibility of using CT to correct specific uptake values (SUVs) for fluorodeoxyglucose (FDG) in patients with nonsolid nodules. Methods: Patients with FDG-PET/CT and thin-section CT were included in this pilot study. Thirty-five adenocarcinomas manifesting as nonsolid nodules were classified into two groups; 90–100\% and 1–89\% lepidic component. SUVmax was corrected based on the CT determination of the proportion of soft tissue component within the cancer (SUVatt). Results: Both SUVmax and SUVatt increased as the percentage of the lepidic component decreased. SUVmax and SUVatt were significantly different between the groups. Conclusion: Extent of invasiveness of nonsolid cancers (as a marker of aggressiveness) can potentially be quantified by PET/CT using a correction method that accounts for the proportion of soft tissue within the tumor.",

author = "Ying Liu and Yankelevitz, \{David F.\} and Lale Kostakoglu and Beasley, \{Mary B.\} and Yu Htwe and Salvatore, \{Mary M.\} and Rowena Yip and Henschke, \{Claudia I.\}",

note = "Publisher Copyright: {\textcopyright} 2018",

year = "2018",

month = nov,

day = "1",

doi = "10.1016/j.clinimag.2018.07.004",

language = "English (US)",

volume = "52",

pages = "157--162",

journal = "Clinical Imaging",

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TY - JOUR

T1 - Updating the role of FDG PET/CT for evaluation of lung cancer manifesting in nonsolid nodules

AU - Liu, Ying

AU - Yankelevitz, David F.

AU - Kostakoglu, Lale

AU - Beasley, Mary B.

AU - Htwe, Yu

AU - Salvatore, Mary M.

AU - Yip, Rowena

AU - Henschke, Claudia I.

PY - 2018/11/1

Y1 - 2018/11/1

N2 - Purpose: To assess the feasibility of using CT to correct specific uptake values (SUVs) for fluorodeoxyglucose (FDG) in patients with nonsolid nodules. Methods: Patients with FDG-PET/CT and thin-section CT were included in this pilot study. Thirty-five adenocarcinomas manifesting as nonsolid nodules were classified into two groups; 90–100% and 1–89% lepidic component. SUVmax was corrected based on the CT determination of the proportion of soft tissue component within the cancer (SUVatt). Results: Both SUVmax and SUVatt increased as the percentage of the lepidic component decreased. SUVmax and SUVatt were significantly different between the groups. Conclusion: Extent of invasiveness of nonsolid cancers (as a marker of aggressiveness) can potentially be quantified by PET/CT using a correction method that accounts for the proportion of soft tissue within the tumor.

AB - Purpose: To assess the feasibility of using CT to correct specific uptake values (SUVs) for fluorodeoxyglucose (FDG) in patients with nonsolid nodules. Methods: Patients with FDG-PET/CT and thin-section CT were included in this pilot study. Thirty-five adenocarcinomas manifesting as nonsolid nodules were classified into two groups; 90–100% and 1–89% lepidic component. SUVmax was corrected based on the CT determination of the proportion of soft tissue component within the cancer (SUVatt). Results: Both SUVmax and SUVatt increased as the percentage of the lepidic component decreased. SUVmax and SUVatt were significantly different between the groups. Conclusion: Extent of invasiveness of nonsolid cancers (as a marker of aggressiveness) can potentially be quantified by PET/CT using a correction method that accounts for the proportion of soft tissue within the tumor.

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UR - https://www.scopus.com/pages/publications/85051049510#tab=citedBy

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DO - 10.1016/j.clinimag.2018.07.004

M3 - Article

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AN - SCOPUS:85051049510

SN - 0899-7071

VL - 52

SP - 157

EP - 162

JO - Clinical Imaging

JF - Clinical Imaging

ER -

Updating the role of FDG PET/CT for evaluation of lung cancer manifesting in nonsolid nodules

Abstract

UN SDGs

All Science Journal Classification (ASJC) codes

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