Upg-2: A urinary pepsinogen variant located on chromosome 1 of the mouse

Jacek M. Szymura; Benjamin A. Taylor; Jan Klein

doi:10.1007/BF00498944

Upg-2: A urinary pepsinogen variant located on chromosome 1 of the mouse

Jacek M. Szymura
, Benjamin A. Taylor
, Jan Klein

Biology

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

Acrylamide gel electrophoresis of mouse urine distinguishes two groups of pepsinogens, the fast-migrating group A and the slow-migrating group B. Inbred mouse strains fall into two categories with respect to group B pepsinogens, one expressing a single-banded and the other a double-banded phenotype. This variation is controlled by a single locus, urinary pepsinogen-2 or Upg-2, which has at least two alleles, Upg-2^s and Upg-2^d. Typing of recombinant inbred strains suggests that the location of the Upg-2 locus is on chromosome 1, in the vicinity of loci coding for other peptidases, namely, Pep-2 and Rnr, and of the Acf-1 locus.

Original language	English (US)
Pages (from-to)	1211-1219
Number of pages	9
Journal	Biochemical Genetics
Volume	20
Issue number	11-12
DOIs	https://doi.org/10.1007/BF00498944
State	Published - Dec 1982

All Science Journal Classification (ASJC) codes

Ecology, Evolution, Behavior and Systematics
Biochemistry
Molecular Biology
Genetics

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title = "Upg-2: A urinary pepsinogen variant located on chromosome 1 of the mouse",

abstract = "Acrylamide gel electrophoresis of mouse urine distinguishes two groups of pepsinogens, the fast-migrating group A and the slow-migrating group B. Inbred mouse strains fall into two categories with respect to group B pepsinogens, one expressing a single-banded and the other a double-banded phenotype. This variation is controlled by a single locus, urinary pepsinogen-2 or Upg-2, which has at least two alleles, Upg-2s and Upg-2d. Typing of recombinant inbred strains suggests that the location of the Upg-2 locus is on chromosome 1, in the vicinity of loci coding for other peptidases, namely, Pep-2 and Rnr, and of the Acf-1 locus.",

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year = "1982",

month = dec,

doi = "10.1007/BF00498944",

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journal = "Biochemical Genetics",

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AU - Szymura, Jacek M.

AU - Taylor, Benjamin A.

AU - Klein, Jan

PY - 1982/12

Y1 - 1982/12

N2 - Acrylamide gel electrophoresis of mouse urine distinguishes two groups of pepsinogens, the fast-migrating group A and the slow-migrating group B. Inbred mouse strains fall into two categories with respect to group B pepsinogens, one expressing a single-banded and the other a double-banded phenotype. This variation is controlled by a single locus, urinary pepsinogen-2 or Upg-2, which has at least two alleles, Upg-2s and Upg-2d. Typing of recombinant inbred strains suggests that the location of the Upg-2 locus is on chromosome 1, in the vicinity of loci coding for other peptidases, namely, Pep-2 and Rnr, and of the Acf-1 locus.

AB - Acrylamide gel electrophoresis of mouse urine distinguishes two groups of pepsinogens, the fast-migrating group A and the slow-migrating group B. Inbred mouse strains fall into two categories with respect to group B pepsinogens, one expressing a single-banded and the other a double-banded phenotype. This variation is controlled by a single locus, urinary pepsinogen-2 or Upg-2, which has at least two alleles, Upg-2s and Upg-2d. Typing of recombinant inbred strains suggests that the location of the Upg-2 locus is on chromosome 1, in the vicinity of loci coding for other peptidases, namely, Pep-2 and Rnr, and of the Acf-1 locus.

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Upg-2: A urinary pepsinogen variant located on chromosome 1 of the mouse

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