Urinary 8-hydroxy-2-deoxyguanosine and cognitive function in puerto rican adults

Xiang Gao, Chao Qiang Lai, Tammy Scott, Jian Shen, Tianxi Cai, Jose M. Ordovas, Katherine L. Tucker

Research output: Contribution to journalArticlepeer-review

14 Scopus citations


DNA oxidative stress has been suggested as an important pathogenic mechanism in cognitive impairment and dementia. With baseline data collected from 2004 to 2008, the authors examined whether urinary 8-hydroxy-2- deoxyguanosine (8-OHdG), a biomarker of global DNA oxidation, was associated with cognitive function in a sample of 1,003 Puerto Rican adults, aged 45-75 years, living in Boston, Massachusetts, and the surrounding area. Cognitive function was measured by using a battery of 7 tests: the Mini-Mental State Examination, word list learning, digit span, clock drawing and figure copying, Stroop, and verbal fluency tests. The primary outcome was a global cognitive score, averaging standardized scores across all cognitive tests. A higher 8-OHdG concentration was significantly associated with lower global cognitive scores, after adjustment for age, education, status of the gene for apolipoprotein E (APOE), and other covariates (Ptrend = 0.01). The difference in the global score, comparing participants in the 2 extreme 8-OHdG quartiles, was-0.11 (95% confidence interval:-0.20,-0.02), which was equivalent to accelerating cognitive aging by about 4 years, as observed in this population. Prospective studies are needed to elucidate whether elevated urinary 8-OHdG concentrations can predict the rate of cognitive decline and incident dementia.

Original languageEnglish (US)
Pages (from-to)271-278
Number of pages8
JournalAmerican journal of epidemiology
Issue number3
StatePublished - Aug 1 2010

All Science Journal Classification (ASJC) codes

  • Epidemiology


Dive into the research topics of 'Urinary 8-hydroxy-2-deoxyguanosine and cognitive function in puerto rican adults'. Together they form a unique fingerprint.

Cite this