TY - JOUR
T1 - Urinary polyamine levels in human cancer
AU - Lipton, Allan
AU - Sheehan, Linda M.
AU - Kessler, Georg Frederick
PY - 1975/2
Y1 - 1975/2
N2 - Polyamine levels (putrescine, spermidine, spermine) were determined in 24‐hour urine samples by a high voltage electrophoresis technique. Normal values were established in 42 normal volunteers. Thirty‐eight of 56 patients with metastatic cancer had two or more levels elevated. Approximately two‐thirds of patients with metastatic adenocarcinoma. metastatic squamous cell cancer or metastatic disease to the liver, lungs, or bones had elevated levels. All 6 patients with localized malignant tumors had elevated urinary polyamine levels. Elevations were also seen in patients with benign prostatic hypertrophy and bronchial adenoma.
AB - Polyamine levels (putrescine, spermidine, spermine) were determined in 24‐hour urine samples by a high voltage electrophoresis technique. Normal values were established in 42 normal volunteers. Thirty‐eight of 56 patients with metastatic cancer had two or more levels elevated. Approximately two‐thirds of patients with metastatic adenocarcinoma. metastatic squamous cell cancer or metastatic disease to the liver, lungs, or bones had elevated levels. All 6 patients with localized malignant tumors had elevated urinary polyamine levels. Elevations were also seen in patients with benign prostatic hypertrophy and bronchial adenoma.
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U2 - 10.1002/1097-0142(197502)35:2<464::AID-CNCR2820350225>3.0.CO;2-8
DO - 10.1002/1097-0142(197502)35:2<464::AID-CNCR2820350225>3.0.CO;2-8
M3 - Article
C2 - 46182
AN - SCOPUS:0016615938
SN - 0008-543X
VL - 35
SP - 464
EP - 468
JO - Cancer
JF - Cancer
IS - 2
ER -