Urinary polyamine levels in patients with gastrointestinal malignancy

Allan Lipton; Linda Sheehan; Harold A. Harvey

doi:10.1002/1097-0142(197512)36:6<2351::AID-CNCR2820360612>3.0.CO;2-6

Urinary polyamine levels in patients with gastrointestinal malignancy

Allan Lipton, Linda Sheehan, Harold A. Harvey

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Abstract

Polyamine levels (putrescine, spermidine, and spermine) were determined in 24‐hour urine samples by a high voltage electrophoresis technique. Eleven of 14 patients with widespread metastatic gastrointestinal cancer had two or more elevated polyamine values. Two patients with cancer confined to the colon and two with cancer spread within the pelvis had two or more elevated polyamine values. Three patients who had all known disease removed by surgery, two patients with gastric lymphoma, and one patient with a villous adenoma of the colon had normal values. Individual values of spermidine and spermine appeared to be elevated more frequently than putrescine values in these patients.

Original language	English (US)
Pages (from-to)	2351-2354
Number of pages	4
Journal	Cancer
Volume	36
Issue number	6 S
DOIs	https://doi.org/10.1002/1097-0142(197512)36:6<2351::AID-CNCR2820360612>3.0.CO;2-6
State	Published - Dec 1975

All Science Journal Classification (ASJC) codes

Oncology
Cancer Research

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10.1002/1097-0142(197512)36:6<2351::AID-CNCR2820360612>3.0.CO;2-6

Cite this

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title = "Urinary polyamine levels in patients with gastrointestinal malignancy",

abstract = "Polyamine levels (putrescine, spermidine, and spermine) were determined in 24‐hour urine samples by a high voltage electrophoresis technique. Eleven of 14 patients with widespread metastatic gastrointestinal cancer had two or more elevated polyamine values. Two patients with cancer confined to the colon and two with cancer spread within the pelvis had two or more elevated polyamine values. Three patients who had all known disease removed by surgery, two patients with gastric lymphoma, and one patient with a villous adenoma of the colon had normal values. Individual values of spermidine and spermine appeared to be elevated more frequently than putrescine values in these patients.",

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T1 - Urinary polyamine levels in patients with gastrointestinal malignancy

AU - Lipton, Allan

AU - Sheehan, Linda

AU - Harvey, Harold A.

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AB - Polyamine levels (putrescine, spermidine, and spermine) were determined in 24‐hour urine samples by a high voltage electrophoresis technique. Eleven of 14 patients with widespread metastatic gastrointestinal cancer had two or more elevated polyamine values. Two patients with cancer confined to the colon and two with cancer spread within the pelvis had two or more elevated polyamine values. Three patients who had all known disease removed by surgery, two patients with gastric lymphoma, and one patient with a villous adenoma of the colon had normal values. Individual values of spermidine and spermine appeared to be elevated more frequently than putrescine values in these patients.

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M3 - Article

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ER -

Urinary polyamine levels in patients with gastrointestinal malignancy

Abstract

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