Urinary polyamine levels in patients with localized malignancy

Allan Lipton; Linda Sheehan; Rodrique Mortel; Harold Harvey

doi:10.1002/1097-0142(197609)38:3<1344::AID-CNCR2820380338>3.0.CO;2-Y

Urinary polyamine levels in patients with localized malignancy

Allan Lipton, Linda Sheehan, Rodrique Mortel, Harold Harvey

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

Abstract

Polyamine levels (putrescine, spermidine, and spermine) were determined in 24‐hour urine samples by a high voltage electrophoresis technique. Twentyfour of 26 patients with localized malignant tumors had two or more elevated urinary polyamine levels. Seven of 12 patients with regional spread of their cancer and five of 11 patients with localized benign and/or noninvasive tumors had elevated urinary polyamine levels. Elevations were seen more frequently in patients with genitourinary, gastrointestinal, and pulmonary tumors and less frequently in patients with gynecologic tumors. Our data suggest that there is no significant difference between the individual or total polyamine levels obtained in patients with localized malignant tumors, and those levels obtained in patients previously studied with widespread metastatic disease.

Original language	English (US)
Pages (from-to)	1344-1347
Number of pages	4
Journal	Cancer
Volume	38
Issue number	3
DOIs	https://doi.org/10.1002/1097-0142(197609)38:3<1344::AID-CNCR2820380338>3.0.CO;2-Y
State	Published - Sep 1976

All Science Journal Classification (ASJC) codes

Oncology
Cancer Research

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10.1002/1097-0142(197609)38:3<1344::AID-CNCR2820380338>3.0.CO;2-Y

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title = "Urinary polyamine levels in patients with localized malignancy",

abstract = "Polyamine levels (putrescine, spermidine, and spermine) were determined in 24‐hour urine samples by a high voltage electrophoresis technique. Twentyfour of 26 patients with localized malignant tumors had two or more elevated urinary polyamine levels. Seven of 12 patients with regional spread of their cancer and five of 11 patients with localized benign and/or noninvasive tumors had elevated urinary polyamine levels. Elevations were seen more frequently in patients with genitourinary, gastrointestinal, and pulmonary tumors and less frequently in patients with gynecologic tumors. Our data suggest that there is no significant difference between the individual or total polyamine levels obtained in patients with localized malignant tumors, and those levels obtained in patients previously studied with widespread metastatic disease.",

author = "Allan Lipton and Linda Sheehan and Rodrique Mortel and Harold Harvey",

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T1 - Urinary polyamine levels in patients with localized malignancy

AU - Lipton, Allan

AU - Sheehan, Linda

AU - Mortel, Rodrique

AU - Harvey, Harold

PY - 1976/9

Y1 - 1976/9

N2 - Polyamine levels (putrescine, spermidine, and spermine) were determined in 24‐hour urine samples by a high voltage electrophoresis technique. Twentyfour of 26 patients with localized malignant tumors had two or more elevated urinary polyamine levels. Seven of 12 patients with regional spread of their cancer and five of 11 patients with localized benign and/or noninvasive tumors had elevated urinary polyamine levels. Elevations were seen more frequently in patients with genitourinary, gastrointestinal, and pulmonary tumors and less frequently in patients with gynecologic tumors. Our data suggest that there is no significant difference between the individual or total polyamine levels obtained in patients with localized malignant tumors, and those levels obtained in patients previously studied with widespread metastatic disease.

AB - Polyamine levels (putrescine, spermidine, and spermine) were determined in 24‐hour urine samples by a high voltage electrophoresis technique. Twentyfour of 26 patients with localized malignant tumors had two or more elevated urinary polyamine levels. Seven of 12 patients with regional spread of their cancer and five of 11 patients with localized benign and/or noninvasive tumors had elevated urinary polyamine levels. Elevations were seen more frequently in patients with genitourinary, gastrointestinal, and pulmonary tumors and less frequently in patients with gynecologic tumors. Our data suggest that there is no significant difference between the individual or total polyamine levels obtained in patients with localized malignant tumors, and those levels obtained in patients previously studied with widespread metastatic disease.

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Urinary polyamine levels in patients with localized malignancy

Abstract

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