Use of peptide-nucleic acid in the "Achilles' heel" approach

Maria Krasilnikova, K. I. Izvol'skii, O. V. Krupnik, Yu S. Lazurkin

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


Peptide-nucleic acid (PNA) was found to prevent DNA methylation if the PNA-binding and the methylation sites are adjacent. It can be used in the "Achilles' heel" method to create artificial rare-cutting restriction endonuclease systems. Application of PNA can expand the possibilities of this approach, which conventionally involves DNA-binding proteins or oligonucleotides.

Original languageEnglish (US)
Pages (from-to)282-284
Number of pages3
JournalMolecular Biology
Issue number29992
StatePublished - Mar 1 1996

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Structural Biology


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