Abstract
Peptide-nucleic acid (PNA) was found to prevent DNA methylation if the PNA-binding and the methylation sites are adjacent. It can be used in the "Achilles' heel" method to create artificial rare-cutting restriction endonuclease systems. Application of PNA can expand the possibilities of this approach, which conventionally involves DNA-binding proteins or oligonucleotides.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 282-284 |
| Number of pages | 3 |
| Journal | Molecular Biology |
| Volume | 30 |
| Issue number | 29992 |
| State | Published - Mar 1 1996 |
All Science Journal Classification (ASJC) codes
- Biophysics
- Structural Biology