Using wearable sensors and machine learning to assess upper limb function in Huntington’s disease

Background: Huntington’s disease, a neurodegenerative disorder, impairs both upper and lower limb function, typically assessed in clinical settings. However, wearable sensors offer the opportunity to monitor real-world data that complements clinical assessments, providing a more comprehensive understanding of disease symptoms. Methods: In this study, we monitor upper limb function in individuals with Huntington’s disease (HD, n = 16), prodromal HD (pHD, n = 7), and controls (CTR, n = 16) using a wrist-worn wearable sensor over a 7-day period. Goal-directed hand movements are detected through a deep learning model, and kinematic features of each movement are analyzed. The collected data is used to predict disease groups and clinical scores using statistical and machine learning models. Results: Here we show that significant differences in goal-directed movement features exist between the groups. Additionally, several of these features strongly correlate with clinical scores. Classification models accurately distinguish between HD, pHD, and CTR individuals, achieving a balanced accuracy of 67% and a recall of 0.72 for the HD group. Regression models effectively predict clinical scores. Conclusions: This study demonstrates the potential of wearable sensors and machine learning to monitor upper limb function in Huntington’s disease, offering a tool for early detection, remote monitoring, and assessing treatment efficacy in clinical trials.