Uterine myxoid leiomyosarcoma with widespread metastases in a cat

T. K. Cooper, B. M. Ronnett, D. S. Ruben, M. C. Zink

Research output: Contribution to journalArticlepeer-review

24 Scopus citations


A 10-year-old domestic shorthair cat was spayed to remove bilateral ovarian masses and an enlarged uterus. Both ovaries were effaced by large, irregular, firm, glistening, white cystic masses filled with clear viscous fluid. The uterine lumen was filled with copious amounts of clear viscous fluid, and the uterus contained multiple, firm, glistening, white nodules. Histologic examination revealed an invasive spindle cell neoplasm with features of malignancy, and extensive hypocellular areas containing an alcian blue-positive myxoid matrix. Tumor cells expressed caldesmon, α-smooth muscle actin, and estrogen receptor but were negative for desmin. The animal was euthanized 1 month later because of suspected local tumor recurrence. At necropsy, the abdominal cavity contained 120 ml of mucoid ascites; multiple tumor nodules were present in the abdominal and thoracic cavities. The clinical behavior and gross, microscopic, and immunohistochemical findings established a diagnosis of myxoid leiomyosarcoma.

Original languageEnglish (US)
Pages (from-to)552-556
Number of pages5
JournalVeterinary Pathology
Issue number4
StatePublished - 2006

All Science Journal Classification (ASJC) codes

  • General Veterinary


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