TY - JOUR
T1 - Utility of echocardiographic radial strain imaging to quantify left ventricular dyssynchrony and predict acute response to cardiac resynchronization therapy
AU - Dohi, Kaoru
AU - Suffoletto, Matthew S.
AU - Schwartzman, David
AU - Ganz, Leonard
AU - Pinsky, Michael R.
AU - Gorcsan, John
N1 - Funding Information:
Dr. Gorcsan was supported in part by National Institutes of Health Award K24 HL04503-01 and American Heart Association National Grant-in-Aid 0050587N.
PY - 2005/7/1
Y1 - 2005/7/1
N2 - Echocardiographic strain imaging was used to quantify radial mechanical dyssynchrony in 38 patients who underwent cardiac resynchronization therapy. Dyssynchrony, defined as the time difference of peak radial strain in the septum versus the posterior wall, was significantly greater in patients with acute hemodynamic responses, and changes in radial dyssynchrony correlated with changes in stroke volume. A <130-ms difference in septal versus posterior wall peak strain when combined with a favorable left ventricular lead position was strongly predictive of immediate improvement in stroke volume with resynchronization therapy (95% sensitivity, 88% specificity), regardless of electrocardiographic QRS duration.
AB - Echocardiographic strain imaging was used to quantify radial mechanical dyssynchrony in 38 patients who underwent cardiac resynchronization therapy. Dyssynchrony, defined as the time difference of peak radial strain in the septum versus the posterior wall, was significantly greater in patients with acute hemodynamic responses, and changes in radial dyssynchrony correlated with changes in stroke volume. A <130-ms difference in septal versus posterior wall peak strain when combined with a favorable left ventricular lead position was strongly predictive of immediate improvement in stroke volume with resynchronization therapy (95% sensitivity, 88% specificity), regardless of electrocardiographic QRS duration.
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U2 - 10.1016/j.amjcard.2005.03.032
DO - 10.1016/j.amjcard.2005.03.032
M3 - Article
C2 - 15979447
AN - SCOPUS:20744450465
SN - 0002-9149
VL - 96
SP - 112
EP - 116
JO - American Journal of Cardiology
JF - American Journal of Cardiology
IS - 1
ER -