Utilization of magnesium for the treatment of chronic pain

Ivan Urits, Jai Won Jung, Ariunzaya Amgalan, Luc Fortier, Anthony Anya, Brendan Wesp, Vwaire Orhurhu, Elyse Mcornett, Alan D. Kaye, Farnad Imani, Giustino Varrassi, Henry Liu, Omar Viswanath

Research output: Contribution to journalArticlepeer-review

25 Scopus citations


Context: The International Association for the Study of Pain (IASP) defines chronic pain as pain that persists or recurs for longer than 3 months. Chronic pain has a significant global disease burden with profound effects on health, quality of life, and socioeconomic costs. Evidence Acquisition: Narrative review. Results: There are several treatment options, including pharmacological therapy, physical rehabilitation, psychological therapies, and surgical interventions, for chronic pain management. Magnesium has been FDA-approved for several indications including hypomagnesemia, arrhythmia, prevention of seizures in eclampsia/preeclampsia, and constipation. Magnesium has been used for numerous off-label uses, notably for acute and chronic pain management. The mechanism of magnesium in pain management is primarily through its action as a voltage-gated antagonist of NMDA receptors, which are involved in pain transduction. Conclusions: This narrative review will focus on the current evidence and data surrounding the utilization of magnesium as a treatment option for chronic pain.

Original languageEnglish (US)
Article numbere112348
Pages (from-to)1-10
Number of pages10
JournalAnesthesiology and Pain Medicine
Issue number1
StatePublished - Feb 2021

All Science Journal Classification (ASJC) codes

  • Anesthesiology and Pain Medicine


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