TY - GEN
T1 - Validation of embedded element method in the prediction of white matter disruption in concussions
AU - Harsha, T. Garimella
AU - Kraft, Reuben H.
N1 - Funding Information:
National Science Foundation through grant OCI0821527
Publisher Copyright:
© 2016 by ASME.
PY - 2016
Y1 - 2016
N2 - A better understanding of the axonal injury would help us develop improved diagnostic tools, protective measures, and rehabilitation treatments. Computational modeling coupled with advanced neuroimaging techniques might be a promising tool for this purpose. However, before the models can be used for real life applications, they need to be validated and cross-verified with real life scenarios to establish the credibility of the model. In this work, progress has been made in validating a human head finite element model with embedded axonal fiber tractography (using embedded element method) using pre-and post-diffusion tensor imaging data (DTI) of a concussed athlete. Fractional anisotropy (FA) was used to determine the microstructural changes during injury. These damaged locations correlated well with the damaged locations observed from the finite element model. This work could be characterized as a first step towards the development of a more comprehensively validated human head finite element model.
AB - A better understanding of the axonal injury would help us develop improved diagnostic tools, protective measures, and rehabilitation treatments. Computational modeling coupled with advanced neuroimaging techniques might be a promising tool for this purpose. However, before the models can be used for real life applications, they need to be validated and cross-verified with real life scenarios to establish the credibility of the model. In this work, progress has been made in validating a human head finite element model with embedded axonal fiber tractography (using embedded element method) using pre-and post-diffusion tensor imaging data (DTI) of a concussed athlete. Fractional anisotropy (FA) was used to determine the microstructural changes during injury. These damaged locations correlated well with the damaged locations observed from the finite element model. This work could be characterized as a first step towards the development of a more comprehensively validated human head finite element model.
UR - http://www.scopus.com/inward/record.url?scp=85011989387&partnerID=8YFLogxK
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U2 - 10.1115/IMECE2016-67785
DO - 10.1115/IMECE2016-67785
M3 - Conference contribution
AN - SCOPUS:85011989387
T3 - ASME International Mechanical Engineering Congress and Exposition, Proceedings (IMECE)
BT - Biomedical and Biotechnology Engineering
PB - American Society of Mechanical Engineers (ASME)
T2 - ASME 2016 International Mechanical Engineering Congress and Exposition, IMECE 2016
Y2 - 11 November 2016 through 17 November 2016
ER -