Variable association of DNA polymerase with the cytoskeletal fractions of resting and dividing cells

Usha K. Srinivas; C. S. Shashikant; M. R. Das

doi:10.1007/BF02702699

Variable association of DNA polymerase with the cytoskeletal fractions of resting and dividing cells

Usha K. Srinivas, C. S. Shashikant, M. R. Das

Research output: Contribution to journal › Article › peer-review

Abstract

A DNA polymerase activity associated with the detergent insoluble cytoskeletal fraction has been identified in dividing and non-dividing rat hepatocytes and a hepatoma (the Zajdela Ascitic Hepatoma). About 35 % of the enzyme is found associated with the cytoskeletal fraction of non-dividing cells as compared to about 3-6 % of the enzyme in dividing cells even though the dividing cells contain larger amounts of the extranuclear enzyme. The properties of the enzyme are similar to those of DNA polymerase-v. It is suggested that the association of the enzyme with the cytoskeletal fraction has functional significance.

Original language	English (US)
Pages (from-to)	231-236
Number of pages	6
Journal	Journal of Biosciences
Volume	9
Issue number	3-4
DOIs	https://doi.org/10.1007/BF02702699
State	Published - Dec 1 1985

All Science Journal Classification (ASJC) codes

General Biochemistry, Genetics and Molecular Biology
General Agricultural and Biological Sciences

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10.1007/BF02702699

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title = "Variable association of DNA polymerase with the cytoskeletal fractions of resting and dividing cells",

abstract = "A DNA polymerase activity associated with the detergent insoluble cytoskeletal fraction has been identified in dividing and non-dividing rat hepatocytes and a hepatoma (the Zajdela Ascitic Hepatoma). About 35 % of the enzyme is found associated with the cytoskeletal fraction of non-dividing cells as compared to about 3-6 % of the enzyme in dividing cells even though the dividing cells contain larger amounts of the extranuclear enzyme. The properties of the enzyme are similar to those of DNA polymerase-v. It is suggested that the association of the enzyme with the cytoskeletal fraction has functional significance.",

author = "Srinivas, {Usha K.} and Shashikant, {C. S.} and Das, {M. R.}",

year = "1985",

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AU - Srinivas, Usha K.

AU - Shashikant, C. S.

AU - Das, M. R.

PY - 1985/12/1

Y1 - 1985/12/1

N2 - A DNA polymerase activity associated with the detergent insoluble cytoskeletal fraction has been identified in dividing and non-dividing rat hepatocytes and a hepatoma (the Zajdela Ascitic Hepatoma). About 35 % of the enzyme is found associated with the cytoskeletal fraction of non-dividing cells as compared to about 3-6 % of the enzyme in dividing cells even though the dividing cells contain larger amounts of the extranuclear enzyme. The properties of the enzyme are similar to those of DNA polymerase-v. It is suggested that the association of the enzyme with the cytoskeletal fraction has functional significance.

AB - A DNA polymerase activity associated with the detergent insoluble cytoskeletal fraction has been identified in dividing and non-dividing rat hepatocytes and a hepatoma (the Zajdela Ascitic Hepatoma). About 35 % of the enzyme is found associated with the cytoskeletal fraction of non-dividing cells as compared to about 3-6 % of the enzyme in dividing cells even though the dividing cells contain larger amounts of the extranuclear enzyme. The properties of the enzyme are similar to those of DNA polymerase-v. It is suggested that the association of the enzyme with the cytoskeletal fraction has functional significance.

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Variable association of DNA polymerase with the cytoskeletal fractions of resting and dividing cells

Abstract

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