Vascular permeability in ocular disease and the role of tight junctions

Kathryn K. Erickson; Jeffrey M. Sundstrom; David A. Antonetti

doi:10.1007/s10456-007-9067-z

Vascular permeability in ocular disease and the role of tight junctions

Kathryn K. Erickson, Jeffrey M. Sundstrom, David A. Antonetti

Research output: Contribution to journal › Article › peer-review

169 Scopus citations

Abstract

Vascular permeability is closely linked with angiogenesis in a number of pathologies. In the retina, the normally well-developed blood-retinal barrier is altered in a host of eye diseases preceding or commensurate with angiogenesis. This review examines the literature regarding the tight junction complex that establishes the blood-retinal barrier focusing on the transmembrane proteins occludin and the claudin family and the membrane associated protein zonula occludens. The changes observed in these proteins associated with vascular and epithelial permeability is discussed. Finally, novel literature addressing the link between the tight junction complex and angiogenesis is considered.

Original language	English (US)
Pages (from-to)	103-117
Number of pages	15
Journal	Angiogenesis
Volume	10
Issue number	2
DOIs	https://doi.org/10.1007/s10456-007-9067-z
State	Published - Jun 2007

All Science Journal Classification (ASJC) codes

Physiology
Clinical Biochemistry
Cancer Research

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/s10456-007-9067-z

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title = "Vascular permeability in ocular disease and the role of tight junctions",

abstract = "Vascular permeability is closely linked with angiogenesis in a number of pathologies. In the retina, the normally well-developed blood-retinal barrier is altered in a host of eye diseases preceding or commensurate with angiogenesis. This review examines the literature regarding the tight junction complex that establishes the blood-retinal barrier focusing on the transmembrane proteins occludin and the claudin family and the membrane associated protein zonula occludens. The changes observed in these proteins associated with vascular and epithelial permeability is discussed. Finally, novel literature addressing the link between the tight junction complex and angiogenesis is considered.",

author = "Erickson, {Kathryn K.} and Sundstrom, {Jeffrey M.} and Antonetti, {David A.}",

note = "Funding Information: Acknowledgements We would like to acknowledge Dr Alistair Barber, Dr Thomas Gardner and Dr Tomoaki Murakami for their kind help in preparing this review and Jeannie Kazy Er-ickson for her artistic rendering. Work on this review was supported by an unrestricted educational grant from Allergan, as well as NIH grant EY012021 and EY016413 (DAA), and the Juvenile Diabetes Research Foundation.",

year = "2007",

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doi = "10.1007/s10456-007-9067-z",

language = "English (US)",

volume = "10",

pages = "103--117",

journal = "Angiogenesis",

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publisher = "Springer Netherlands",

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T1 - Vascular permeability in ocular disease and the role of tight junctions

AU - Erickson, Kathryn K.

AU - Sundstrom, Jeffrey M.

AU - Antonetti, David A.

N1 - Funding Information: Acknowledgements We would like to acknowledge Dr Alistair Barber, Dr Thomas Gardner and Dr Tomoaki Murakami for their kind help in preparing this review and Jeannie Kazy Er-ickson for her artistic rendering. Work on this review was supported by an unrestricted educational grant from Allergan, as well as NIH grant EY012021 and EY016413 (DAA), and the Juvenile Diabetes Research Foundation.

PY - 2007/6

Y1 - 2007/6

N2 - Vascular permeability is closely linked with angiogenesis in a number of pathologies. In the retina, the normally well-developed blood-retinal barrier is altered in a host of eye diseases preceding or commensurate with angiogenesis. This review examines the literature regarding the tight junction complex that establishes the blood-retinal barrier focusing on the transmembrane proteins occludin and the claudin family and the membrane associated protein zonula occludens. The changes observed in these proteins associated with vascular and epithelial permeability is discussed. Finally, novel literature addressing the link between the tight junction complex and angiogenesis is considered.

AB - Vascular permeability is closely linked with angiogenesis in a number of pathologies. In the retina, the normally well-developed blood-retinal barrier is altered in a host of eye diseases preceding or commensurate with angiogenesis. This review examines the literature regarding the tight junction complex that establishes the blood-retinal barrier focusing on the transmembrane proteins occludin and the claudin family and the membrane associated protein zonula occludens. The changes observed in these proteins associated with vascular and epithelial permeability is discussed. Finally, novel literature addressing the link between the tight junction complex and angiogenesis is considered.

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Vascular permeability in ocular disease and the role of tight junctions

Abstract

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