VCN-Releasable sialic acid and gangliosides in human neuroblastomas

Stephen J. Shochat; Arthur B. Abt; Cara Lynne Schengrund

doi:10.1016/0022-3468(77)90019-7

VCN-Releasable sialic acid and gangliosides in human neuroblastomas

Stephen J. Shochat, Arthur B. Abt, Cara Lynne Schengrund

Department of Biochemistry and Molecular Biology

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

The ganglioside pattern and VCN-releasable sialic acid residues of six human neuroblastomas were studied. There was no correlation between VCN-releasable sialic acid and prognosis. The ganglioside patterns were more complex in those cases with an expected good prognosis as reflected by the presence of trisialoganglioside. The complexity of the ganglioside pattern did not always corelate with the histologic grade of the tumor. These results suggest the ganglioside pattern may serve as a chemical marker for predicting the prognosis in patients with neuroblastomas.

Original language	English (US)
Pages (from-to)	413-418
Number of pages	6
Journal	Journal of pediatric surgery
Volume	12
Issue number	3
DOIs	https://doi.org/10.1016/0022-3468(77)90019-7
State	Published - Jun 1977

All Science Journal Classification (ASJC) codes

Surgery
Pediatrics, Perinatology, and Child Health

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10.1016/0022-3468(77)90019-7

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@article{41f0781a32e24d6facc4c4f16020a829,

title = "VCN-Releasable sialic acid and gangliosides in human neuroblastomas",

abstract = "The ganglioside pattern and VCN-releasable sialic acid residues of six human neuroblastomas were studied. There was no correlation between VCN-releasable sialic acid and prognosis. The ganglioside patterns were more complex in those cases with an expected good prognosis as reflected by the presence of trisialoganglioside. The complexity of the ganglioside pattern did not always corelate with the histologic grade of the tumor. These results suggest the ganglioside pattern may serve as a chemical marker for predicting the prognosis in patients with neuroblastomas.",

author = "Shochat, {Stephen J.} and Abt, {Arthur B.} and Schengrund, {Cara Lynne}",

note = "Funding Information: From the Division of Pediatric Surgery, the Deportment of Surgery, and the Deportments of Pathology. and Biological Chemistry, Milton S. Hershey Medical Center, Pennsylvania State University, Hershey, PA. Presented before the 25th Annual Meeting of the American Academy of Pediatrics. Surgical Section, Chicago. Illinois. October 17-I 9. I976 Supported by PHS research grant CA I4319 from the Notional Cancer Institute. Address reprint requests to: S. J. Shochot, M.D.. Division of Pediatric Surgery, Dept. of Surgery. M. S. Hershey Medical Center, Pennsylvonio State University, Hershey, PA. 17033. 0 I977 by Grune & Stratton. Inc.",

year = "1977",

month = jun,

doi = "10.1016/0022-3468(77)90019-7",

language = "English (US)",

volume = "12",

pages = "413--418",

journal = "Journal of pediatric surgery",

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publisher = "W.B. Saunders",

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TY - JOUR

T1 - VCN-Releasable sialic acid and gangliosides in human neuroblastomas

AU - Shochat, Stephen J.

AU - Abt, Arthur B.

AU - Schengrund, Cara Lynne

N1 - Funding Information: From the Division of Pediatric Surgery, the Deportment of Surgery, and the Deportments of Pathology. and Biological Chemistry, Milton S. Hershey Medical Center, Pennsylvania State University, Hershey, PA. Presented before the 25th Annual Meeting of the American Academy of Pediatrics. Surgical Section, Chicago. Illinois. October 17-I 9. I976 Supported by PHS research grant CA I4319 from the Notional Cancer Institute. Address reprint requests to: S. J. Shochot, M.D.. Division of Pediatric Surgery, Dept. of Surgery. M. S. Hershey Medical Center, Pennsylvonio State University, Hershey, PA. 17033. 0 I977 by Grune & Stratton. Inc.

PY - 1977/6

Y1 - 1977/6

N2 - The ganglioside pattern and VCN-releasable sialic acid residues of six human neuroblastomas were studied. There was no correlation between VCN-releasable sialic acid and prognosis. The ganglioside patterns were more complex in those cases with an expected good prognosis as reflected by the presence of trisialoganglioside. The complexity of the ganglioside pattern did not always corelate with the histologic grade of the tumor. These results suggest the ganglioside pattern may serve as a chemical marker for predicting the prognosis in patients with neuroblastomas.

AB - The ganglioside pattern and VCN-releasable sialic acid residues of six human neuroblastomas were studied. There was no correlation between VCN-releasable sialic acid and prognosis. The ganglioside patterns were more complex in those cases with an expected good prognosis as reflected by the presence of trisialoganglioside. The complexity of the ganglioside pattern did not always corelate with the histologic grade of the tumor. These results suggest the ganglioside pattern may serve as a chemical marker for predicting the prognosis in patients with neuroblastomas.

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U2 - 10.1016/0022-3468(77)90019-7

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JO - Journal of pediatric surgery

JF - Journal of pediatric surgery

IS - 3

ER -

VCN-Releasable sialic acid and gangliosides in human neuroblastomas

Abstract

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