Vegan diet-based lifestyle program rapidly lowers homocysteine levels

David J. DeRose, Zeno L. Charles-Marcel, Judith M. Jamison, Joshua E. Muscat, Marc A. Braman, Gerard D. McLane, J. Keith Mullen

Research output: Contribution to journalArticlepeer-review

15 Scopus citations


Background. Plasma homocysteine levels have been directly associated with cardiac disease risk. Current research raises concerns as to whether comprehensive lifestyle approaches including a plant-based diet may interact with other known modulators of homocysteine levels. Methods. We report our observations of homocysteine levels in 40 self-selected subjects who participated in a vegan diet-based lifestyle program. Each subject attended a residential lifestyle change program at the Lifestyle Center of America in Sulphur, Oklahoma and had fasting plasma total homocysteine measured on enrollment and then after 1 week of lifestyle intervention. The intervention included a vegan diet, moderate physical exercise, stress management and spirituality enhancement sessions, group support, and exclusion of tobacco, alcohol, and caffeine. B vitamin supplements known to reduce blood homocysteine levels were not provided. Results. Subjects' mean homocysteine levels fell 13%: from 8.66 μmol/L (SD 2.7 μmol/L) to 7.53 μmol/L (SD 2.12 μmol/L; P < 0.0001). Subgroup analysis showed that homocysteine decreased across a range of demographic and diagnostic categories. Conclusions. Our results suggest that broad-based lifestyle interventions favorably impact homocysteine levels. Furthermore, analysis of Lifestyle Center of America program components suggests that other factors in addition to B vitamin intake may be involved in the observed homocysteine lowering. (C) 2000 American Health Foundation and Academic Press.

Original languageEnglish (US)
Pages (from-to)225-233
Number of pages9
JournalPreventive Medicine
Issue number3
StatePublished - Mar 2000

All Science Journal Classification (ASJC) codes

  • Epidemiology
  • Public Health, Environmental and Occupational Health


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