TY - JOUR
T1 - Venous pressure and dyspnea on exertion in cardiac failure
T2 - Was Tinsley Randolph Harrison right?
AU - Haouzi, Philippe
N1 - Copyright:
Copyright 2009 Elsevier B.V., All rights reserved.
PY - 2009/5/30
Y1 - 2009/5/30
N2 - More than 70 years ago, Harrison and his group proposed that in the absence of pulmonary edema, an increased systemic venous pressure could be a major source of dyspnea upon exertion in cardiac patients. Harrison provided evidence that in resting animals systemic venous pressure can affect ventilatory control through afferent information originating from the right side of the central circulation (i.e. right ventricle and large veins) via the vagus nerves. This review explores the concept that "increased venous pressure acts as a cause of dyspnea", which emerged from the remarkable work performed by Harrison and co-workers. Their conclusion will be however extended by developing the hypothesis that the load imposed on the venous blood returning from the skeletal muscles during any muscular activity is sensed by slow conducting muscle afferent fibers and provides a source of dyspnea in heart failure patients.
AB - More than 70 years ago, Harrison and his group proposed that in the absence of pulmonary edema, an increased systemic venous pressure could be a major source of dyspnea upon exertion in cardiac patients. Harrison provided evidence that in resting animals systemic venous pressure can affect ventilatory control through afferent information originating from the right side of the central circulation (i.e. right ventricle and large veins) via the vagus nerves. This review explores the concept that "increased venous pressure acts as a cause of dyspnea", which emerged from the remarkable work performed by Harrison and co-workers. Their conclusion will be however extended by developing the hypothesis that the load imposed on the venous blood returning from the skeletal muscles during any muscular activity is sensed by slow conducting muscle afferent fibers and provides a source of dyspnea in heart failure patients.
UR - http://www.scopus.com/inward/record.url?scp=67349163250&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=67349163250&partnerID=8YFLogxK
U2 - 10.1016/j.resp.2008.09.001
DO - 10.1016/j.resp.2008.09.001
M3 - Article
C2 - 18824145
AN - SCOPUS:67349163250
SN - 1569-9048
VL - 167
SP - 101
EP - 106
JO - Respiratory Physiology and Neurobiology
JF - Respiratory Physiology and Neurobiology
IS - 1
ER -