TY - JOUR
T1 - Ventricular volume and dementia progression in the Cardiovascular Health Study
AU - Carmichael, Owen T.
AU - Kuller, Lewis H.
AU - Lopez, Oscar L.
AU - Thompson, Paul M.
AU - Dutton, Rebecca A.
AU - Lu, Allen
AU - Lee, Sharon E.
AU - Lee, Jessica Y.
AU - Aizenstein, Howard J.
AU - Meltzer, Carolyn Cidis
AU - Liu, Yanxi
AU - Toga, Arthur W.
AU - Becker, James T.
N1 - Funding Information:
This work was supported by CHS Ancillary Studies “Predictors of Alzheimer's disease in mild cognitive impairment” (PI: Oscar L. Lopez, M.D), and “Relationship between cognitive function testing, APOE, brain MRI, and risk of dementia and specific types of dementia in the CHS” (PI: Lewis H. Kuller, M.D.); and NIH grants NS07391, MH064625, AG05133, DA015900-01, MH01077, EB001561, RR019771, RR021813, AG016570, AG20098, AG15928.
PY - 2007/3
Y1 - 2007/3
N2 - Elevated cerebral ventricular volume may be associated with dementia risk and progression. A fully-automated technique that agreed highly with radiological readings was used to estimate lateral ventricle volume on MR scans done at baseline in 1997-99 of 377 subjects in the Cardiovascular Health Study (CHS) from the Pittsburgh Center. 327 subjects were normal or diagnosed with mild cognitive impairment (MCI) at baseline and were evaluated 4 years later. Baseline ventricular volume was analyzed in multivariate models with age, gender, education level, presence and incidence of cerebral infarcts, and dementia category (normal, MCI, or dementia) at baseline and follow-up as fixed effects. Ventricular volume at baseline was significantly higher among subjects normal at baseline and demented 4 years later. Age, gender, education level, and dementia progression were significant factors affecting ventricular volume. Ventricular volume was higher in dementia compared to MCI, higher in MCI compared to controls, and higher in Possible-Alzheimer's-disease (AD) dementia compared to Probable-AD. Larger ventricles in healthy subjects may indicate susceptibility to, or progression of, dementia-related pathology.
AB - Elevated cerebral ventricular volume may be associated with dementia risk and progression. A fully-automated technique that agreed highly with radiological readings was used to estimate lateral ventricle volume on MR scans done at baseline in 1997-99 of 377 subjects in the Cardiovascular Health Study (CHS) from the Pittsburgh Center. 327 subjects were normal or diagnosed with mild cognitive impairment (MCI) at baseline and were evaluated 4 years later. Baseline ventricular volume was analyzed in multivariate models with age, gender, education level, presence and incidence of cerebral infarcts, and dementia category (normal, MCI, or dementia) at baseline and follow-up as fixed effects. Ventricular volume at baseline was significantly higher among subjects normal at baseline and demented 4 years later. Age, gender, education level, and dementia progression were significant factors affecting ventricular volume. Ventricular volume was higher in dementia compared to MCI, higher in MCI compared to controls, and higher in Possible-Alzheimer's-disease (AD) dementia compared to Probable-AD. Larger ventricles in healthy subjects may indicate susceptibility to, or progression of, dementia-related pathology.
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U2 - 10.1016/j.neurobiolaging.2006.01.006
DO - 10.1016/j.neurobiolaging.2006.01.006
M3 - Article
C2 - 16504345
AN - SCOPUS:33846622336
SN - 0197-4580
VL - 28
SP - 389
EP - 397
JO - Neurobiology of Aging
JF - Neurobiology of Aging
IS - 3
ER -