Versatile routes toward functional, water-soluble nanoparticles via trifluoroethylester-PEG-thiol ligands

Andrew H. Latham, Mary Elizabeth Williams

Research output: Contribution to journalArticlepeer-review

73 Scopus citations


This paper reports the synthesis of a trifluoroethylester-PEG-thiol ligand (TFEE-PEG-SH) and its use to create water-soluble, chemically functional Au metal and FePt magnetic nanoparticles. The trifluoroethylester terminus facilitates attachment of any primary-amine-containing molecule via amide bond formation at room temperature without the use of coupling agents. Three possible routes of nanoparticle functionalization are demonstrated: synthesis of Au nanoparticles in the presence of functionalized R-PEG-SH; ligand-exchange of R-PEG-SH onto both Au and FePt nanoparticles; and exchange of TFEE-PEG-SH onto Au nanoparticles followed by subsequent amide condensation. A series of primary-amine-containing molecules, including biotin and fluorescamine, are easily attached to the water-soluble particles, and the resulting materials are characterized by NMR, UV-visible absorption, and emission spectroscopies.

Original languageEnglish (US)
Pages (from-to)4319-4326
Number of pages8
Issue number9
StatePublished - Apr 25 2006

All Science Journal Classification (ASJC) codes

  • General Materials Science
  • Condensed Matter Physics
  • Surfaces and Interfaces
  • Spectroscopy
  • Electrochemistry


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