Vilsmeier reagent, NaHSe and diclofenac acid chloride: One-pot synthesis of a novel selenoindolinone with potent anticancer activity

Ana Carolina Ruberte; Carlos Aydillo; Arun K. Sharma; Carmen Sanmartín; Daniel Plano

doi:10.1039/d0ra07332f

Vilsmeier reagent, NaHSe and diclofenac acid chloride: One-pot synthesis of a novel selenoindolinone with potent anticancer activity

Ana Carolina Ruberte
, Carlos Aydillo
, Arun K. Sharma
, Carmen Sanmartín
, Daniel Plano

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

An effective and straightforward synthesis of 3-seleno functionalized indolinone (5) involving Vilsmeier reagent is presented. Likewise, a procedure to achieve lactamization of diclofenac with excellent yields by using hydrides is also ascertained. Compound 5 exhibited impressive growth inhibition in most of the cell lines in an NCI-60 panel, particularly towards resistant breast cancer cells.

Original language	English (US)
Pages (from-to)	38404-38408
Number of pages	5
Journal	RSC Advances
Volume	10
Issue number	63
DOIs	https://doi.org/10.1039/d0ra07332f
State	Published - Oct 19 2020

All Science Journal Classification (ASJC) codes

General Chemistry
General Chemical Engineering

Access to Document

10.1039/d0ra07332f

Cite this

@article{1d848f0fdcbe4ae6910c27e980ee878b,

title = "Vilsmeier reagent, NaHSe and diclofenac acid chloride: One-pot synthesis of a novel selenoindolinone with potent anticancer activity",

abstract = "An effective and straightforward synthesis of 3-seleno functionalized indolinone (5) involving Vilsmeier reagent is presented. Likewise, a procedure to achieve lactamization of diclofenac with excellent yields by using hydrides is also ascertained. Compound 5 exhibited impressive growth inhibition in most of the cell lines in an NCI-60 panel, particularly towards resistant breast cancer cells.",

author = "Ruberte, \{Ana Carolina\} and Carlos Aydillo and Sharma, \{Arun K.\} and Carmen Sanmart{\'i}n and Daniel Plano",

note = "Publisher Copyright: {\textcopyright} 2020 The Royal Society of Chemistry.",

year = "2020",

month = oct,

day = "19",

doi = "10.1039/d0ra07332f",

language = "English (US)",

volume = "10",

pages = "38404--38408",

journal = "RSC Advances",

issn = "2046-2069",

publisher = "Royal Society of Chemistry",

number = "63",

}

TY - JOUR

T1 - Vilsmeier reagent, NaHSe and diclofenac acid chloride

T2 - One-pot synthesis of a novel selenoindolinone with potent anticancer activity

AU - Ruberte, Ana Carolina

AU - Aydillo, Carlos

AU - Sharma, Arun K.

AU - Sanmartín, Carmen

AU - Plano, Daniel

PY - 2020/10/19

Y1 - 2020/10/19

N2 - An effective and straightforward synthesis of 3-seleno functionalized indolinone (5) involving Vilsmeier reagent is presented. Likewise, a procedure to achieve lactamization of diclofenac with excellent yields by using hydrides is also ascertained. Compound 5 exhibited impressive growth inhibition in most of the cell lines in an NCI-60 panel, particularly towards resistant breast cancer cells.

AB - An effective and straightforward synthesis of 3-seleno functionalized indolinone (5) involving Vilsmeier reagent is presented. Likewise, a procedure to achieve lactamization of diclofenac with excellent yields by using hydrides is also ascertained. Compound 5 exhibited impressive growth inhibition in most of the cell lines in an NCI-60 panel, particularly towards resistant breast cancer cells.

UR - https://www.scopus.com/pages/publications/85094912507

UR - https://www.scopus.com/pages/publications/85094912507#tab=citedBy

U2 - 10.1039/d0ra07332f

DO - 10.1039/d0ra07332f

M3 - Article

AN - SCOPUS:85094912507

SN - 2046-2069

VL - 10

SP - 38404

EP - 38408

JO - RSC Advances

JF - RSC Advances

IS - 63

ER -

Vilsmeier reagent, NaHSe and diclofenac acid chloride: One-pot synthesis of a novel selenoindolinone with potent anticancer activity

Abstract

All Science Journal Classification (ASJC) codes

Access to Document

Other files and links

Fingerprint

Cite this