Viral Load Kinetics of Severe Acute Respiratory Syndrome Coronavirus 2 in Hospitalized Individuals with Coronavirus Disease 2019

James Regan, James P. Flynn, Alexandra Rosenthal, Hannah Jordan, Yijia Li, Rida Chishti, Francoise Giguel, Heather Corry, Kendyll Coxen, Jesse Fajnzylber, Elizabeth Gillespie, Daniel R. Kuritzkes, Nir Hacohen, Marcia B. Goldberg, Michael R. Filbin, Xu G. Yu, Lindsey Baden, Ruy M. Ribeiro, Alan S. Perelson, Jessica M. ConwayJonathan Z. Li

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) kinetics remain understudied, including the impact of remdesivir. In hospitalized individuals, peak sputum viral load occurred in week 2 of symptoms, whereas viremia peaked within 1 week of symptom-onset, suggesting early systemic seeding of SARS-CoV-2. Remdesivir treatment was associated with faster viral decay.

Original languageEnglish (US)
Article numberofab153
JournalOpen Forum Infectious Diseases
Volume8
Issue number8
DOIs
StatePublished - Aug 1 2021

All Science Journal Classification (ASJC) codes

  • Oncology
  • Infectious Diseases

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