Viral Load Kinetics of Severe Acute Respiratory Syndrome Coronavirus 2 in Hospitalized Individuals with Coronavirus Disease 2019

James Regan; James P. Flynn; Alexandra Rosenthal; Hannah Jordan; Yijia Li; Rida Chishti; Francoise Giguel; Heather Corry; Kendyll Coxen; Jesse Fajnzylber; Elizabeth Gillespie; Daniel R. Kuritzkes; Nir Hacohen; Marcia B. Goldberg; Michael R. Filbin; Xu G. Yu; Lindsey Baden; Ruy M. Ribeiro; Alan S. Perelson; Jessica M. Conway; Jonathan Z. Li

doi:10.1093/ofid/ofab153

Viral Load Kinetics of Severe Acute Respiratory Syndrome Coronavirus 2 in Hospitalized Individuals with Coronavirus Disease 2019

James Regan
, James P. Flynn
, Alexandra Rosenthal
, Hannah Jordan
, Yijia Li
, Rida Chishti
, Francoise Giguel
, Heather Corry
, Kendyll Coxen
, Jesse Fajnzylber
, Elizabeth Gillespie
, Daniel R. Kuritzkes
, Nir Hacohen
, Marcia B. Goldberg
, Michael R. Filbin
, Xu G. Yu
, Lindsey Baden
, Ruy M. Ribeiro
, Alan S. Perelson
, Jessica M. Conway

Jonathan Z. Li

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) kinetics remain understudied, including the impact of remdesivir. In hospitalized individuals, peak sputum viral load occurred in week 2 of symptoms, whereas viremia peaked within 1 week of symptom-onset, suggesting early systemic seeding of SARS-CoV-2. Remdesivir treatment was associated with faster viral decay.

Original language	English (US)
Article number	ofab153
Journal	Open Forum Infectious Diseases
Volume	8
Issue number	8
DOIs	https://doi.org/10.1093/ofid/ofab153
State	Published - Aug 1 2021

All Science Journal Classification (ASJC) codes

Oncology
Infectious Diseases

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10.1093/ofid/ofab153

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Regan, J., Flynn, J. P., Rosenthal, A., Jordan, H., Li, Y., Chishti, R., Giguel, F., Corry, H., Coxen, K., Fajnzylber, J., Gillespie, E., Kuritzkes, D. R., Hacohen, N., Goldberg, M. B., Filbin, M. R., Yu, X. G., Baden, L., Ribeiro, R. M., Perelson, A. S., ... Li, J. Z. (2021). Viral Load Kinetics of Severe Acute Respiratory Syndrome Coronavirus 2 in Hospitalized Individuals with Coronavirus Disease 2019. Open Forum Infectious Diseases, 8(8), Article ofab153. https://doi.org/10.1093/ofid/ofab153

@article{2471423fe61d462bb6bbc6281433792c,

title = "Viral Load Kinetics of Severe Acute Respiratory Syndrome Coronavirus 2 in Hospitalized Individuals with Coronavirus Disease 2019",

abstract = "Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) kinetics remain understudied, including the impact of remdesivir. In hospitalized individuals, peak sputum viral load occurred in week 2 of symptoms, whereas viremia peaked within 1 week of symptom-onset, suggesting early systemic seeding of SARS-CoV-2. Remdesivir treatment was associated with faster viral decay.",

author = "James Regan and Flynn, \{James P.\} and Alexandra Rosenthal and Hannah Jordan and Yijia Li and Rida Chishti and Francoise Giguel and Heather Corry and Kendyll Coxen and Jesse Fajnzylber and Elizabeth Gillespie and Kuritzkes, \{Daniel R.\} and Nir Hacohen and Goldberg, \{Marcia B.\} and Filbin, \{Michael R.\} and Yu, \{Xu G.\} and Lindsey Baden and Ribeiro, \{Ruy M.\} and Perelson, \{Alan S.\} and Conway, \{Jessica M.\} and Li, \{Jonathan Z.\}",

note = "Publisher Copyright: {\textcopyright} 2021 The Author(s) 2021. Published by Oxford University Press on behalf of Infectious Diseases Society of America.",

year = "2021",

month = aug,

day = "1",

doi = "10.1093/ofid/ofab153",

language = "English (US)",

volume = "8",

journal = "Open Forum Infectious Diseases",

issn = "2328-8957",

publisher = "Oxford University Press",

number = "8",

}

Regan, J, Flynn, JP, Rosenthal, A, Jordan, H, Li, Y, Chishti, R, Giguel, F, Corry, H, Coxen, K, Fajnzylber, J, Gillespie, E, Kuritzkes, DR, Hacohen, N, Goldberg, MB, Filbin, MR, Yu, XG, Baden, L, Ribeiro, RM, Perelson, AS, Conway, JM & Li, JZ 2021, 'Viral Load Kinetics of Severe Acute Respiratory Syndrome Coronavirus 2 in Hospitalized Individuals with Coronavirus Disease 2019', Open Forum Infectious Diseases, vol. 8, no. 8, ofab153. https://doi.org/10.1093/ofid/ofab153

TY - JOUR

T1 - Viral Load Kinetics of Severe Acute Respiratory Syndrome Coronavirus 2 in Hospitalized Individuals with Coronavirus Disease 2019

AU - Regan, James

AU - Flynn, James P.

AU - Rosenthal, Alexandra

AU - Jordan, Hannah

AU - Li, Yijia

AU - Chishti, Rida

AU - Giguel, Francoise

AU - Corry, Heather

AU - Coxen, Kendyll

AU - Fajnzylber, Jesse

AU - Gillespie, Elizabeth

AU - Kuritzkes, Daniel R.

AU - Hacohen, Nir

AU - Goldberg, Marcia B.

AU - Filbin, Michael R.

AU - Yu, Xu G.

AU - Baden, Lindsey

AU - Ribeiro, Ruy M.

AU - Perelson, Alan S.

AU - Conway, Jessica M.

AU - Li, Jonathan Z.

PY - 2021/8/1

Y1 - 2021/8/1

N2 - Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) kinetics remain understudied, including the impact of remdesivir. In hospitalized individuals, peak sputum viral load occurred in week 2 of symptoms, whereas viremia peaked within 1 week of symptom-onset, suggesting early systemic seeding of SARS-CoV-2. Remdesivir treatment was associated with faster viral decay.

AB - Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) kinetics remain understudied, including the impact of remdesivir. In hospitalized individuals, peak sputum viral load occurred in week 2 of symptoms, whereas viremia peaked within 1 week of symptom-onset, suggesting early systemic seeding of SARS-CoV-2. Remdesivir treatment was associated with faster viral decay.

UR - https://www.scopus.com/pages/publications/85118179921

UR - https://www.scopus.com/pages/publications/85118179921#tab=citedBy

U2 - 10.1093/ofid/ofab153

DO - 10.1093/ofid/ofab153

M3 - Article

C2 - 34430669

AN - SCOPUS:85118179921

SN - 2328-8957

VL - 8

JO - Open Forum Infectious Diseases

JF - Open Forum Infectious Diseases

IS - 8

M1 - ofab153

ER -

Viral Load Kinetics of Severe Acute Respiratory Syndrome Coronavirus 2 in Hospitalized Individuals with Coronavirus Disease 2019

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