Abstract
Vitamin A is required in the diet of all vertebrates, and is metabolized intracellularly to retinoic acid (RA), which is well known as a regulator of cell proliferation and differentiation. RA activates nuclear retinoid receptors and regulates a wide variety of genes. This chapter first discusses vitamin A nutrition and metabolism, and then how inflammation affects the metabolism of vitamin A compounds. Clinically, RA and several analogs are used in the treatment of skin disorders. Vitamin A deficiency is a risk factor for infectious disease. This chapter discusses the role of vitamin A in the immune system, especially in the regulation of T cell differentiation and in innate immunity.
| Original language | English (US) |
|---|---|
| Title of host publication | Diet, Immunity and Inflammation |
| Publisher | Elsevier Ltd |
| Pages | 221-243 |
| Number of pages | 23 |
| ISBN (Print) | 9780857090379 |
| DOIs | |
| State | Published - Sep 2013 |
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
All Science Journal Classification (ASJC) codes
- General Agricultural and Biological Sciences
- General Biochemistry, Genetics and Molecular Biology
- General Medicine
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