Vitamin A gastrointestinal absorption in persons with Down's syndrome

S. M. Pueschel, C. Hillemeier, M. Caldwell, K. Senft, C. Mevs, J. C. Pezzullo

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ABSTRACT. The total daily vitamin A intake, physical signs associated with vitamin A deficiency, and the response to a vitamin A challenge were studied in 33 patients with Down's syndrome and in 14 intellectually normal persons (comparison group). The evaluation of detailed dietary histories revealed that the study subjects' mean daily vitamin A intake was similar to the recommended daily allowance for adults and that there was no significant difference of the mean daily vitamin A intake between study and comparison groups (5029 IU and 5706 IU, respectively). Subjects with Down's syndrome had more symptoms usually seen in patients with hypovitaminosis A than the persons in the comparison group. The baseline serum vitamin A levels in the Down's syndrome and comparison groups were within the normal range (106.0 μg/dl and 136.5 μg/dl, respectively). The vitamin A absorption curve of persons with Down's syndrome paralleled that of normal individuals and no significant difference of vitamin A levels between study and comparison groups was observed except for the 6‐h values. Also, the absorption differential ( ‐0‐h value) did not show a significant difference between the two groups. Thus, these investigations do not support previous reports of significantly decreased vitamin A absorption in individuals with Down's syndrome.

Original languageEnglish (US)
Pages (from-to)269-275
Number of pages7
JournalJournal of Intellectual Disability Research
Issue number3
StatePublished - Jun 1990

All Science Journal Classification (ASJC) codes

  • Rehabilitation
  • Arts and Humanities (miscellaneous)
  • Neurology
  • Clinical Neurology
  • Psychiatry and Mental health


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