Vitamin A toxicity and vitamin E deficiency in a rabbit colony

Mark B. St. Claire, Mary J. Kennett, Cynthia L. Besch-Williford

Research output: Contribution to journalArticlepeer-review

14 Scopus citations


Vitamin A toxicosis and vitamin E deficiency was diagnosed in a commercial rabbit-breeding colony and was associated with reproductive abnormalities, abortions, and poor survivability of kits in the breeding colony. Paresis and muscular dystrophy were noted in juvenile rabbits. Another group of New Zealand White rabbits from the same commercial colony was used to assess the effect of vitamin E-based therapy on clinical signs, reproduction, and vitamin A and E serum and liver levels. Blood samples were taken before and after dietary changes and vitamin E therapy. Serum vitamin E remained low after feeding a diet containing the recommended levels of vitamin E. Administration of vitamin E for 2 weeks lowered the serum vitamin A levels and increased the vitamin E serum and liver levels. In conclusion, vitamin E therapy appears to be an effective treatment for hypervitaminosis A.

Original languageEnglish (US)
Pages (from-to)26-30
Number of pages5
JournalContemporary Topics in Laboratory Animal Science
Issue number4
StatePublished - Jul 1 2004

All Science Journal Classification (ASJC) codes

  • Animal Science and Zoology
  • veterinary(all)


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